AI Article Synopsis
- A study examined the connection between certain genetic rearrangements (BCR/ABL+) and different blood cell types in 15 patients with chronic myeloid leukemia.
- The analysis showed that major blood cell types like neutrophils, monocytes, eosinophils, erythroids, and CD34(+) cells were all significantly involved in nearly all patients, with no major differences observed between minor and major BCR/ABL+ cases.
- Involvement of B- and NK-cells was seen in a smaller percentage of cases, specifically 43% and 31%, respectively, while T-cells were rarely present; minor BCR/ABL+ patients had a higher incidence of B- and NK-cell involvement compared
Article Abstract
The relationship between different Abelson/breakpoint cluster region (BCR/ABL+) gene rearrangements and the involvement of different haematopoietic cell lineages were investigated in 15 chronic myeloid leukaemia patients. Analysis of purified cell populations confirmed the involvement of the neutrophil (89%), monocytic (89%), eosinophil (88%), erythroid (100%), and CD34(+) cells (100%) in virtually all patients, without differences between minor BCR/ABL+ and major BCR/ABL+ cases; BCR/ABL+ B- and natural killer (NK)-cells were detected in 43% and 31% of cases, respectively, whereas BCR/ABL+ T-cells were rare (7%). All three minor BCR/ABL+ patients showed involvement of both B- and NK-cells, which was infrequent (27%, P = 0.06 and 10%, P = 0.01) among major BCR/ABL+ cases.
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| http://dx.doi.org/10.1111/j.1365-2141.2005.05944.x | DOI Listing |
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