The influence of pH medium on ATP-ase activity of skeletal muscles myosin has been investigated. The mathematical simulation, which reflects the ATP-hydrolase biochemical reactions after pH medium changes in the muscular fiber was also carried out.
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Acupunct Med
December 2024
Institute of Acupuncture and Meridian, Anhui University of Chinese Medicine, Hefei, China.
Objective: To determine the effect of electroacupuncture (EA) on β-adrenergic receptor (β-AR) and post-receptor protein kinase A (PKA) signaling pathway after acute myocardial ischemia (MI).
Methods: An MI model was established by ligating the left anterior descending coronary artery of wild-type (WT) C57/BL and β-AR mice (heterozygous for β-AR gene deletion). EA treatment was administered at HT5-HT7 or LU9-LU8.
Antibiotics (Basel)
May 2024
Institute of General and Physical Chemistry, University of Belgrade, 11158 Belgrade, Serbia.
(immortelle) essential oil is one of the most popular essential oils worldwide and it has many beneficial properties, including antimicrobial. However, in this plant, the chemical diversity of the essential oil is very pronounced. The aim of this work was to process the GC-MS results of four samples of essential oil of Serbian origin by chemometric tools, and evaluate the antimicrobial activity in vitro and in silico.
View Article and Find Full Text PDFRev Med Liege
February 2024
Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Liège, Belgique.
Mavacamten (Camzyos®) is a myosin modulator which reduces the interactions between myosin and actin. These are overly activated in hypertrophic cardiomyopathy (HCM), a source of exaggerated ventricular contractility, energy loss, and impairment of diastolic function (relaxation). The Food and Drug Administration (FDA) and the European Medication Agency (EMA) approved mavacamten for the treatment of symptomatic obstructive HCM (NYHA class II or III) in adult patients in 2022 and 2023, respectively.
View Article and Find Full Text PDFZhonghua Kou Qiang Yi Xue Za Zhi
January 2024
Department of Endodontics, School and Hospital of Stomatology, Fujian Medical University & Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University & Institute of Stomatology, Fujian Medical University & Research Center of Oral Tissue Engineering, Fujian Medical University, Fuzhou 350002, China.
To investigate the role and related mechanisms of the LiaSR two-component system in acid tolerance and biofilm formation abilities of (Sm) 593. The growth curves of various Sm strains in pH=5.5 brian heart infusion (BHI) medium were analyzed.
View Article and Find Full Text PDFReprod Sci
July 2023
Department of Physiology, College of Graduate Studies, Midwestern University, Downers Grove, IL, 60515, USA.
During pregnancy, the uterus undergoes several modifications under the influence of hormonal and mechanical stimuli. We hypothesize that while most of these modifications are reverted during involution, some of the physiological properties of the uterus are permanently altered. To investigate this hypothesis, we conducted motility experiments to evaluate the contractility response of uterine tissue samples from non-pregnant virgin and proven breeder female rats to oxytocin (10 to 10 M).
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