In experiments on the adult white laboratory rats the correlation of tissue respiration and some morpho- and stereometric characteristics of mitochondria in lung tissue under breathing by air and gas mixture with 7% O2 in N2 was investigated. The following agents were used as modulators: indomethacin, a blockator of cyclooxygenase way of arachidonic acid metabolism; quercetin and linoleil of hydroxamic acid, blockators of lipooxygenase way ofarachidonic acid metabolism; taurine, an antihypoxant and energy source under hypoxic conditions; lipin-antihypoxant with significant membrane protective effect. It was shown, that the respiration intensity of tissue homogenate, not only of its mitochondrial fraction, closely connected with structural organization of mitochondria. It was demonstrated that changes of O2 concentration in gas mixture lead to the alteration of interrelation between O2 consumption and stereometric characteristics of mitochondria: in normoxia the intimate correlation was established with number of mitochondria and its total surface; in hypoxia such correlation was established with mitochondria diameter and number of structurally damage organelles. Pharmacological modulation factors play in this process not so significant role.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Exploring the Potential Application of an Innovative Post-Weld Finishing Method in Butt-Welded Joints of Stainless Steels and Aluminum Alloys.
Materials (Basel)
April 2024
Department of Manufacturing and Production Engineering, Rzeszow University of Technology, al. Powst. Warszawy 8, 35-959 Rzeszow, Poland.
The prerequisite of the weld bead finishing is intricately linked to the quality of the welded joint. It constitutes the final, yet pivotal, stage in its formation, significantly influencing the reliability of structural components and machines. This article delineates an innovative post-weld surface finishing method, distinguished by the movement of a specialized cutting tool along a butt weld.
View Article and Find Full Text PDFTemplate-free efficacious morphology of electrosynthesized polyaniline/β-cyclodextrin host-guest complex on Au/rGO modified electrode for removal and recovery of rare-earth and heavy elements from seawater.
Chemosphere
May 2024
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China.
Global water pollution and scarcity of water resources are turning increasingly into serious threats to the survival of all living organisms on Earth. This study offers an influent strategy for the electrosynthesis of reduced graphene oxide/polyaniline/β-cyclodextrin (rGO/PAni/βCD) nanocomposite and its application to the removal/recovery of heavy elements (HEs) and rare-earth elements (REEs). Besides physicochemical and electrochemical studies, the surface morphological and statistical properties of fabricated nanocomposite electrode were examined.
View Article and Find Full Text PDFInfluence of Innovative Post-Weld Finishing Method on Bead Surface Quality.
Materials (Basel)
July 2023
Department of Engineering Sciences, Faculty of Marine Engineering, Gdynia Maritime University, 81-87 Morska St., 81-225 Gdynia, Poland.
The article describes an innovative post-weld surface finishing method, which is characterized by moving a specialized cutting tool along a butt weld. The aforementioned method is unique for the machining allowance, which is treated as the weld bead height and is removed in one step with one pass of the cutting tool. The tool is equipped on one side with linearly arranged tooth-shaped cutting elements, with the adjacent teeth height changing and increasing according to the direction of the feed.
View Article and Find Full Text PDFMetrological Aspects of Assessing Surface Topography and Machining Accuracy in Diagnostics of Grinding Processes.
Materials (Basel)
March 2023
Faculty of Mechanical Engineering, Institute of Applied Mechanics, Poznan University of Technology, 3 Piotrowo St., 60-965 Poznań, Poland.
The paper presents probabilistic aspects of diagnostics of grinding processes with consideration of metrological aspects of evaluation of topography of machined surfaces and selected problems of assessment of machining accuracy. The processes of creating the geometric structure of the ground surface are described. It was pointed out that the distribution of features important for process diagnostics depends on the mechanism of cumulative effects of random disturbances.
View Article and Find Full Text PDFAutoregulation and Autoinhibition of the Main NO Synthase Isoforms (Brief Review).
Sovrem Tekhnologii Med
March 2024
Head of Laboratory of Chemical and Biotechnological Synthesis; Moscow Institute of Physics and Technology (National Research University), 9 Institutskiy Per., Dolgoprudny, Moscow Region, 141701, Russia.
Nitric oxide (II) (NO) is the most important mediator of a wide range of physiological and pathophysiological processes. It is synthesized by NO synthases (NOSs), which have three main isoforms differing from each other in terms of activation and inhibition features, levels of NO production, subcellular localization, etc. At the same time, all isoforms are structurally very similar, and these differences are determined by NOS autoregulatory elements.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!