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Lower levels of kainate receptors, but not AMPA or NMDA receptors, in Brodmann's area (BA) 9, but not BA 10, from a subgroup of people with schizophrenia who have a marked deficit in cortical muscarinic M1 receptors.
Schizophr Res
December 2024
The Molecular Psychiatry Laboratory, The Florey, Parkville, Victoria, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia. Electronic address:
Article Synopsis
- The study investigates the differences in receptor binding in the brains of people with schizophrenia, specifically focusing on the Muscarinic Receptor Deficit subgroup (MRDS), which shows reduced binding to the M1 receptor.
- Researchers confirmed MRDS by measuring [H]pirenzepine binding and then examined the binding of other glutamate receptors ([H]kainate, [H]AMPA, [H]NMDA) in Brodmann's areas 9 and 10 to see if there were subgroup-specific differences.
- Results showed that while M1 and kainate receptor binding was lower in BA 9 and BA 10 for MRDS individuals, other glutamate receptors (AMPA and NMDA) did not
The role of fatty acid-binding protein 5 and 7 on locomotor, anxiety and social behavior: Interaction with NMDA signaling.
Neurosci Lett
July 2024
Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY, United States; Department of Psychology, State University at Buffalo, Buffalo, NY, United States. Electronic address:
The endocannabinoid system has been shown to be a powerful mediator of anxiety, learning and memory, as well as nociception behaviors. Exogenous cannabinoids like delta-9-tetrahydrocannabinol mimic the naturally occurring endogenous cannabinoids found in the mammalian central and peripheral nervous system. The hydrophobic properties of endocannabinoids mean that these psychoactive compounds require help with cellular transport.
View Article and Find Full Text PDFSubanesthetic S-ketamine does not acutely alter striatal dopamine transporter binding in healthy Sprague Dawley female rats.
Synapse
July 2024
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Article Synopsis
- * S-ketamine is a new fast-acting treatment for those who don't respond to other medications, but its mechanism of action is still unclear and needs further investigation.
- * Recent studies using advanced imaging techniques didn't find any changes in dopamine transporter levels in the brain after administering S-ketamine, suggesting these changes are not linked to its rapid antidepressant effects; more research is needed to understand its action.
Characterization of tritiated JNJ-GluN2B-5 (3-[H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors.
J Neurochem
September 2024
Neuroscience Discovery, Janssen Research & Development, LLC, La Jolla, California, USA.
Here, we describe the characterization of a radioligand selective for GluN2B-containing NMDA receptors, 3-[H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone ([H]-JNJ- GluN2B-5). In rat cortical membranes, the compound bound to a single site, and the following kinetic parameters were measured; association rate constant K = 0.0066 ± 0.
View Article and Find Full Text PDFCharacterization of ()- and ()-[F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing -Methyl-d-Aspartate Receptors.
ACS Chem Neurosci
December 2023
Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
The -methyl-d-aspartate receptor (NMDAR) subtype 2B (GluN1/2B) is implicated in various neuropathologies. Given the lack of a validated radiofluorinated positron emission tomography (PET) probe for the imaging of GluN1/2B receptors, we comprehensively investigated the enantiomers of [F]OF-NB1 in rodents. Particularly, the ()- and ()- enantiomers were evaluated using docking, autoradiography, PET imaging, and biodistribution studies.
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