AI Article Synopsis

  • The study involved patients with resectable breast cancer without additional risk factors, focusing on those who were receptor-negative or had axillary lymph node metastasis.
  • The treatment regimen included four cycles of CEF chemotherapy followed by four cycles of Docetaxel, with a total of 14 patients analyzed, ranging in age from 37 to 69 years.
  • Adverse events were noted, including leukocytopenia and diarrhea, but the overall response rate was promising, with 78.5% of patients showing significant improvement, demonstrating the regimen's safety and effectiveness.

Article Abstract

Subjects: The subjects were patients with resectable breast cancer who visited our department between August 2003 and November 2004, did not have any other risk factors defined in the St. Gallen Consensus Conference,and were receptor-negative or had axillary lymph node metastasis.

Methods: The histological type, ER, PgR, HER2, and histological grade were evaluated by needle biopsy. Four courses of CEF (5-FU: 500 mg/m(2)+EPI: 75 mg/m(2)+CPA: 500 mg/m(2)) were performed at 3-week intervals, followed by 4 courses of Docetaxel (70 mg/m(2)).

Results: Treatment was performed in 14 patients including a male. Their age ranged from 37 to 69 years (mean, 55.3 years). Stage IIA was observed in 5 patients, IIB in 4, IIIA in 1, and IIIB in 4. In patients with Grade 3 or more, leukocytopenia was observed in 7 patients and diarrhea in 1 as adverse events. CR was obtained in 6 patients, PR in 5, and NC in 3 (response rate, 78.5%). Pathological examination showed pCR in 1 patient and pPR in 10 (response rate, 78.5%). Of the 10 patients with pPR, 2 showed a state near pCR.

Discussion: Our results showed the safety and effectiveness of preoperative chemotherapy with CEF followed by Docetaxel.

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