AI Article Synopsis
- Garlic has chemopreventive properties against various cancers, but the effects can vary depending on the preparation used.
- Researchers examined the effects of aged garlic extract (AGE) on colon cancer in rats induced by a cancer-causing chemical, DMH, over 20 weeks.
- The study found that rats consuming a diet with 4% AGE had fewer colon tumors and reduced cell proliferation, indicating that AGE may help prevent colon cancer.
Article Abstract
Garlic has been reported to have chemopreventive effects against a variety of cancers. However, different garlic preparations contain different constituents. We investigated the chemopreventive effect of aged garlic extract (AGE), an odorless product from prolonged extraction of fresh garlic, on colon carcinogenesis and cell proliferation in 1,2-dimethylhydrazine (DMH)-induced colon neoplastic rats. Rats were given weekly subcutaneous injections of DMH (20 mg/kg) for 20 wk, and fed either a basal diet or one containing 4% AGE. Serum from AGE-treated rats contained detectable S-allylcysteine. The AGE diet significantly reduced the number of colon tumors and aberrant crypt foci compared to the basal diet. Cell proliferation of normal-appearing colonic mucosa was assessed by MIB-5 immunohistochemistry. AGE treatment significantly decreased the mean MIB-5-labeling index. These findings suggest AGE has a chemopreventive effect on colon carcinogenesis through suppression of cell proliferation.
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| http://dx.doi.org/10.1093/jn/136.3.847S | DOI Listing |
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