AI Article Synopsis
- * Madindoline is not available from natural sources, so a synthetic method has been developed to produce it.
- * Tests on various madindoline analogues revealed several strong candidates for fighting IL-6-dependent diseases.
Article Abstract
A research program is under way to develop a series of madindoline-based inhibitors targeting interleukin 6. Such inhibitors will have potential use in fighting a variety of diseases for which no effective therapeutic drugs currently exist. Madindoline is no longer available from natural sources. Consequently, we have developed a purely synthetic route to ensure a supply of the compound. The synthesis of a range of analogues is described, all of which were evaluated for their inhibitory activity against the growth of IL-6-dependent 7TDI cells. From these assays, several synthetic madindoline analogues were identified as highly promising candidates for further development.
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| http://dx.doi.org/10.1016/j.bmcl.2006.01.107 | DOI Listing |
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