People with PTSD often report difficulties remembering day to day information unrelated to their traumatic episode. In addition, structural and functional imaging techniques have identified abnormalities in the brains of people with PTSD in regions known to be important for memory functioning. Nevertheless, studies investigating cognitive functioning in people with PTSD have reported widely varying results. The aim of this review is to investigate studies reporting performance on tests of episodic memory. Specifically, papers were examined in relation to the hypothesised memory functions of the frontal lobes, the hippocampus and the amygdala. It is concluded that while there is reasonable evidence of frontal lobe involvement, memory deficits caused by hippocampal involvement have been more difficult to detect. There are no published studies looking at the involvement of the amygdala although preliminary evidence suggests that people with PTSD do have memory deficits resulting from dysfunction of this structure. Reasons for the inconclusiveness of the results are discussed.
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http://dx.doi.org/10.1016/j.cpr.2005.12.004 | DOI Listing |
PLoS One
January 2025
Interventional Psychiatry Program, St. Michael's Hospital, Toronto, Ontario, Canada.
Background: Posttraumatic stress disorder (PTSD) affects 3.9% of the general population. While massed cognitive processing therapy (CPT) has demonstrated efficacy in treating chronic PTSD, a substantial proportion of patients still continue to meet PTSD criteria after treatment, highlighting the need for novel therapeutic approaches.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Post-traumatic Stress Disorder (PTSD), Major Depressive Disorder (MDD), and Adjustment Disorder (AdjD) are highly prevalent among military personnel, often presenting diagnostic challenges due to overlapping symptoms and reliance on self-reporting. The amygdala, particularly the basolateral complex involved in fear-related memory formation and extinction recall, plays a crucial role in emotional processing. Abnormalities in these amygdala nuclei are implicated in PTSD and may distinguish it from other disorders like MDD and AdjD, where these mechanisms are less central.
View Article and Find Full Text PDFBMJ Ment Health
January 2025
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Background: Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). We aimed to identify predictors and develop models for the prediction of depression and PTSD symptoms at 6 months post-TBI.
Methods: We analysed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study.
JMIR Form Res
January 2025
Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Background: Individuals with co-occurring posttraumatic stress disorder (PTSD) and HIV are at high-risk for negative HIV-related outcomes, including low adherence to antiretroviral therapy, faster disease progression, more hospitalizations, and almost twice the rate of death. Despite high rates of PTSD in persons with HIV (PWH) and poor HIV-related health outcomes associated with PTSD, an effective evidence-based treatment for PTSD symptoms in PWH does not exist.
Objective: This study aimed to describe the adaptation and theater testing of an evidence-based intervention designed for people with co-occurring PTSD and HIV.
Psychol Trauma
January 2025
Department of Psychiatry and Behavioral Sciences, Rush University Medical Center.
Objective: Although traumatic exposures are common, only a small percentage of people exposed to trauma go on to develop posttraumatic stress disorder (PTSD). This phenomenon suggests that there may be psychological factors that influence posttraumatic recovery trajectories. Beliefs about one's ability to cope with traumatic events have been proposed as a mechanism of posttraumatic recovery.
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