AI Article Synopsis
- * A study reports the successful use of linezolid, an oxazolidinone antibiotic, to treat this infection in two very low birth weight premature infants.
- * Linezolid was administered intravenously and resulted in complete recovery and organism clearance, indicating it is a safe and effective treatment for these vulnerable patients.
Article Abstract
Glycopeptide-resistant Enterococcus faecium has emerged as an important nosocomial pathogen with limited therapeutic options. Here we report the successful treatment of glycopeptide-resistant E. faecium infection in two very low birth weight premature infants with the new oxazolidinone linezolid. Treatment with linezolid at a dosage of 10 mg/kg every 8 h intravenously for a duration of 16 days and 14 days, respectively, was well tolerated and led to complete clinical recovery and clearance of the organism from all body sites. The two cases support the clinical efficacy and safety of linezolid in very low birth weight premature neonates with glycopeptide-resistant E. faecium infections.
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| http://dx.doi.org/10.1016/j.ijantimicag.2005.11.006 | DOI Listing |
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