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Ten years' single surgeon experience of excision and primary anastomosis urethroplasty for traumatic urethral stricture: an analysis of risk factors for urethral stricture recurrence.
Arch Ital Urol Androl
January 2025
Urology Department, Faculty of Medicine, Universitas Brawijaya, Saiful Anwar General Hospital, Malang.
Introduction: Excision and primary anastomosis (EPA) urethroplasty is the standard treatment for traumatic urethral strictures, but managing them remains challenging for urologists. Identifying factors leading to EPA urethroplasty failure benefits both patients and surgeons. This study aims to analyze risk factors for urethral stricture recurrence after one-year follow-up of EPA urethroplasty.
View Article and Find Full Text PDFEpigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes.
BMC Genomics
January 2025
Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Background: Few studies have explored the association between DNA methylation and physical activity. The aim of this study was to evaluate the association of objectively measured hours of sedentary behavior (SB) and moderate physical activity (MPA) with DNA methylation. We further aimed to explore the association between SB or MPA related CpG sites and cardiometabolic traits, gene expression, and genetic variation.
View Article and Find Full Text PDFModeling based dynamics mechanism and pathway of liposome penetration in multicellular tumor spheroid for liposome optimization.
Int J Pharm
January 2025
Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. Electronic address:
Liposomes are widely recognized as effective drug delivery systems, characterized by biodegradability, biocompatibility, and ability to minimize toxicity. However, liposome-based nanotechnology has not demonstrated superior anti-tumor efficacy due to their limited intratumor penetration. Strategies to improve the tumor delivery efficiency of nanomedicine remain to be developed.
View Article and Find Full Text PDFReliability of artificial intelligence-driven markerless motion capture in gait analyses of healthy adults.
PLoS One
January 2025
Department of Kinesiology and Sport Sciences, University of Miami, Coral Gables, FL, United States of America.
The KinaTrax markerless motion capture system, used extensively in the analysis of baseball pitching and hitting, is currently being adapted for use in clinical biomechanics. In clinical and laboratory environments, repeatability is inherent to the quality of any diagnostic tool. The KinaTrax system was assessed on within- and between-session reliability for gait kinematic and spatiotemporal parameters in healthy adults.
View Article and Find Full Text PDFThe Role of Feedback Training on Early Postoperative Recovery and Anxiety Scores in an Ambulatory Surgical Unit: A Secular Trend Study.
J Crit Care Med (Targu Mures)
October 2024
Ariel University, School of Health Sciences, Ariel, Israel.
Background: We used a ten-item postoperative quality of recovery score (QoR-10) to assess the perioperative quality of care in an in-hospital ambulatory surgical unit.
Methods: In Phase 1 of this secular trend study (n=300 patients, 3-months duration), we collected QoR-10 scores and potential confounders, including type of anesthesia and surgery; co-morbidities; and anesthesia components of the Amsterdam scale-measured anxiety scores. Phase 2 was the one-month performance feedback learning phase in which modifiable variables identified in Phase 1 were translated to actionable steps, reinforcing the already existing routine of our department's clinical practices, including pain, shivering and anxiety.
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