The relationship between bone and fat formation within the bone marrow microenvironment is complex and remains an area of active investigation. Classical in vitro and in vivo studies strongly support an inverse relationship between the commitment of bone marrow-derived mesenchymal stem cells or stromal cells to the adipocyte and osteoblast lineage pathways. In this review, we focus on the recent literature exploring the mechanisms underlying these differentiation events and discuss their implications relevant to osteoporosis and regenerative medicine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jcb.20777 | DOI Listing |
Publication Analysis
Top Keywords
bone fat
8
playing bone
4
fat relationship
4
relationship bone
4
fat formation
4
formation bone
4
bone marrow
4
marrow microenvironment
4
microenvironment complex
4
complex remains
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!