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The impact of diet-induced maternal obesity on offspring airway hyperresponsiveness was studied in a diversity outbred mouse model that mirrors human genetic diversity. Female mice were started on high-fat or regular diet 8 weeks before breeding and throughout pregnancy and lactation. After weaning, all offspring were fed a regular diet.
View Article and Find Full Text PDFThe direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity.
Cell Rep Med
January 2025
Medical Research Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China; Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; General Surgery Department, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Beijing Laboratory of Oral Health, Capital Medical University School of Basic Medicine, Beijing 100069, China; Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Beijing 100050, China. Electronic address:
Article Synopsis
- Acarbose plays a significant role in reducing inflammation related to obesity and insulin resistance by influencing adipose tissue macrophages (ATMs).
- Acarbose promotes the growth of beneficial gut bacteria that produce propionic acid, which helps inhibit the proinflammatory M1-like ATMs.
- The study shows that acarbose directly targets and inhibits these inflammatory macrophages, suggesting its potential for therapeutic use in managing obesity and insulin resistance.
Luteolin alleviates muscle atrophy, mitochondrial dysfunction and abnormal FNDC5 expression in high fat diet-induced obese rats and palmitic acid-treated C2C12 myotubes.
J Nutr Biochem
January 2025
Department of Pharmaceutical Science, Wuhan University, Wuhan 430000, China. Electronic address:
Obesity is associated with a series of skeletal muscle impairments and dysfunctions, which are characterized by metabolic disturbances and muscle atrophy. Luteolin is a phenolic phytochemical with broad pharmacological activities. The present study aimed to evaluate the protective effects of Luteolin on muscle function and explore the potential mechanisms in high-fat diet (HFD)-induced obese rats and palmitic acid (PA)-treated C2C12 myotubes.
View Article and Find Full Text PDFNatriuretic peptide receptor-C perturbs mitochondrial respiration in white adipose tissue.
J Lipid Res
September 2024
Department of Cardiovascular Medicine, Department of Hypertension, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Natriuretic peptide receptor-C (NPR-C) is highly expressed in adipose tissues and regulates obesity-related diseases; however, the detailed mechanism remains unknown. In this research, we aimed to explore the potential role of NPR-C in cold exposure and high-fat/high-sugar (HF/HS) diet-induced metabolic changes, especially in regulating white adipose tissue (WAT) mitochondrial function. Our findings showed that NPR-C expression, especially in epididymal WAT (eWAT), was reduced after cold exposure.
View Article and Find Full Text PDFObesity impairs ciliary function and mucociliary clearance in the murine airway epithelium.
Am J Physiol Lung Cell Mol Physiol
September 2024
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
Obesity is a risk factor for increased morbidity and mortality in viral respiratory infection. Mucociliary clearance (MCC) in the airway is the primary host defense against viral infections. However, the impact of obesity on MCC is unclear, prompting this study.
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