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Fe/Mo-Based Lipid Peroxidation Nanoamplifier Combined with Adenosine Immunometabolism Regulation to Augment Anti-Breast Cancer Immunity.
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Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 DingJiaQiao Road, Nanjing, 210009, P. R. China.
Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional strategies neglect the increase in the immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that the adenosine A2A receptor (A2AR) is significantly expressed in breast cancer and positively associated with regulatory T (Treg) cells.
View Article and Find Full Text PDFEfficient stabilizing effect of low-dose zein/xanthan gum nanoparticles at the oil-water interface.
Int J Biol Macromol
January 2025
Department of Nutrition and Health, China Agricultural University, Beijing 100193, China. Electronic address:
The inherent propensity for aggregation necessitates the use of high concentrations of protein-polysaccharide nanoparticles to achieve stable Pickering emulsions. This study employed xanthan gum (XG) to mitigate the pronounced aggregation of zein nanoparticles by structure construction, thereby enhancing the emulsifying efficiency of zein/XG (Z/XG) nanoparticles. The Z/XG nanoparticles displayed significantly enhanced dispersity, with the absolute ζ-potential increasing from 6.
View Article and Find Full Text PDFqPRF: A system to accelerate population receptive field modeling.
Neuroimage
January 2025
Division of Arts and Sciences, NYU Shanghai, 567 West Yangsi Road, Pudong New District, 200124, Shanghai, China; Center for Neural Science, New York University, 4 Washington Place, NY, 10003, NY, USA; NYU-ECNU Institute of Brain and Cognitive Science, 3663 Zhongshan Road North, Putuo District, 200062, Shanghai, China. Electronic address:
BOLD response can be fitted using the population receptive field (PRF) model to reveal how visual input is represented on the cortex (Dumoulin and Wandell, 2008). Fitting the PRF model costs considerable time, often requiring days to analyze BOLD signals for a small cohort of subjects. We introduce the qPRF ("quick PRF"), a system for accelerated PRF modeling that reduced the computation time by a factor ¿1,000 without losing goodness-of-fit when compared to another widely available PRF modeling package (Kay et al.
View Article and Find Full Text PDFUnveiling the Diverse Principles for Developing Sprayable Hydrogels for Biomedical Applications.
Biomacromolecules
January 2025
Center of Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Sprayable hydrogels have emerged as a transformative innovation in biomedical technology, offering a versatile, efficient, and minimally invasive platform for various clinical applications. They form gels upon tissue contact, enabling seamless application on even complex surfaces. This property is especially useful in wound care, drug delivery, and tissue engineering, where localized and sustained release of therapeutics is essential.
View Article and Find Full Text PDFAttention-deficit/hyperactivity disorder (ADHD) is one of the most common pediatric psychiatric disorders and is frequently diagnosed and treated by pediatricians. Stimulant medications are the first-line treatment for ADHD but may not be a good fit for many patients due to side effects, inadequate treatment response, or family preference. Non-stimulant ADHD medications provide a useful alternative for patients that cannot tolerate stimulants, have an incomplete treatment response to stimulants, are at risk for stimulant diversion, or whose family prefers to avoid stimulants.
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