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http://dx.doi.org/10.1038/scientificamerican0206-22 | DOI Listing |
J Exp Zool A Ecol Integr Physiol
January 2020
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona.
McNeill Alexander demonstrated that compliant tendons could improve locomotor performance by decoupling muscle length changes from joint movements and mechanical energy fluctuations. This was revolutionary for our understanding of animal locomotion, but also highlighted the limitations of our understanding of the contractile performance of muscle under the dynamic conditions relevant to movement. This review addresses the potential for biological compliance to not only alter the demands on muscle but also fundamentally change contractile performance.
View Article and Find Full Text PDFMamm Genome
November 1994
Department of Microbiology and Immunology, Jefferson Cancer Institute, Philadelphia, Pennsylvania 19107.
The fibrillin genes, FBN1 and FBN2, encode large extracellular matrix glycoproteins involved in the structure and function of microfibrils. Mutations in FBN1 are found in patients with Marfan syndrome, a heritable connective tissue disease that primarily affects the cardiovascular, ocular, and skeletal systems. We extended the studies of these genes by determining their chromosomal position in the mouse genome.
View Article and Find Full Text PDFBiol Reprod
March 1988
Department of Obstetrics & Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Mice bearing gene mutations that, among other effects, render the males infertile were examined. Serum testosterone was within the normal range (0.8-1.
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