A new explanation for the evolution of particles near a roadway is proposed. The explanation starts with data that suggest that small (<15 nm) liquid nanoparticles shed semivolatile organics (
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A self-hygroscopic, rapidly self-gelling polysaccharide-based sponge with robust wet adhesion for non-compressible hemorrhage control and infected wounds healing.
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Department of Orthopedic Surgery, First People's Hospital of Foshan, Foshan, Guangdong, 528000, PR China.
Uncontrollable non-compressible hemorrhage and traumatic infection have been major causes of mortality and disability in both civilian and military populations. A dressing designed for point-of-care control of non-compressible hemorrhage and prevention of traumatic infections represents an urgent medical need. Here, a novel self-gelling sponge OHN@ε-pL is developed, integrating N-succinimidyl ester oxidized hyaluronic acid (OHN) and ε-poly-L-lysine (ε-pL).
View Article and Find Full Text PDFGene therapy in hemophilia: the dawn of a new era.
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January 2025
Dipartimento di Fisiopatologia Medico-chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italia.
Hemophilia A and B are hereditary bleeding disorders associated with the X chromosome, stemming from genetic defects in the coding of coagulation factor (F)VIII or FIX protein, leading to partial or complete deficiency. In the absence of effective prophylaxis, these deficiencies can result in irreversible joint damage, known as hemophilic arthropathy, and subsequent disability. Despite advancements in hemophilia treatment, individuals with severe forms of the disease continue to face a high risk of bleeding, particularly in instances of trauma or major surgical procedures.
View Article and Find Full Text PDFA Comparative Review on the Production of Factor VIII in Human and Non-human Hosts.
Curr Pharm Des
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School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Hemophilia A (HA) is an inherited condition that is characterized by a lack of coagulation factor VIII (FVIII), which is needed for blood clotting. To produce recombinant factor VIII (rFVIII) for treatment, innovative methods are required. This study presents a thorough examination of the genetic engineering and biotechnological methods that are essential for the production of this complex process.
View Article and Find Full Text PDFEvaluation of the actinia-shaped composite coagulant for removal of algae in water: Role of charge density.
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State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address:
A series of novel cationic modified actinia-shaped composite coagulant (AMS-C), with similar tentacle length and distribution but different charge density (CD), was successfully designed and fabricated by combination of a cationic graft starch and attapulgite (ATP). AMS-C shows a high efficiency in coagulative removal of Microcystis aeruginosa from water over a wide pH range. The algae-harvesting efficiency of optimized AMS-C can reach to 92.
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Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.
The incidence of heat-related illnesses and heatstroke continues to rise amidst global warming. Hyperthermia triggers inflammation, coagulation, and progressive multiorgan dysfunction, and, at levels above 40 °C, can even lead to cell death. Blood cells, particularly granulocytes and platelets, are highly sensitive to heat, which promotes proinflammatory and procoagulant changes.
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