Background: A 59-year-old man on exogenous androgen therapy presented with a clinically palpable prostate nodule confined to one lobe on endorectal examination. Serum prostate-specific antigen was 3.4 ng/ml. Bone scintigraphy and baseline CT were reportedly negative.
Investigations: Physical examination, laboratory evaluation, endorectal MRI of the prostate, cystoscopy and biopsy.
Diagnosis: Poorly differentiated adenocarcinoma of the prostate, with invasion of the urinary bladder.
Management: Neoadjuvant hormonal therapy, followed by radiation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ncpuro0328 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CEST imaging combined with H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice.
Alzheimers Res Ther
January 2025
Radiology Department, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Background: The imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis that has shown potential neuroprotective effects in various neurodegenerative disorders. However, whether riluzole can improve Glu and GABA homeostasis in AD brain and its related mechanism of action remain unknown.
View Article and Find Full Text PDFManagement of female para-urethral cyst with dyspareunia: a case report.
J Med Case Rep
January 2025
Department of Urology, SRM Institute of Science and Technology, SRM Nagar, Chengalpattu, Kattankulathur, Tamilnadu, 603203, India.
Background: The diagnosis and management of female genital conditions (Rodriguez et al. in Clin Anat 34(1):103-107, 2020. https://doi.
View Article and Find Full Text PDFOptimizing hip MRI: enhancing image quality and elevating inter-observer consistency using deep learning-powered reconstruction.
BMC Med Imaging
January 2025
Department of Magnetic Resonance Imaging, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
Background: Conventional hip joint MRI scans necessitate lengthy scan durations, posing challenges for patient comfort and clinical efficiency. Previously, accelerated imaging techniques were constrained by a trade-off between noise and resolution. Leveraging deep learning-based reconstruction (DLR) holds the potential to mitigate scan time without compromising image quality.
View Article and Find Full Text PDF[Neurological diagnosis of lower urinary tract dysfunction].
Urologie
January 2025
KontinenzZentrum AG Zürich, Witellikerstrasse 40, 8032, Zürich, Schweiz.
Background: Neurophysiological investigations are infrequently utilized in the diagnostic workup of lower urinary tract symptoms (LUTS).
Objective: To determine the potential contributions of neurophysiological assessments in the diagnostic process of LUTS and their integration into systemic neurological and psychosomatic disorders.
Materials And Methods: This study elucidates the role of neurophysiological tests specific to pelvic floor diagnostics, namely pudendal nerve somatosensory-evoked potentials (SEP) and external anal sphincter electromyography (EMG), through the presentation of two clinical case reports.
The diagnostic accuracy of ultrasound in assessing anterior cruciate ligament tears: a systematic review and meta-analysis.
Skeletal Radiol
January 2025
Department of Orthopaedic Surgery, Tufts Medical Center, Boston, MA, USA.
Background: Advances in technology and affordability of ultrasound (US) have expanded its use in the evaluation of musculoskeletal injuries. However, US accuracy for diagnosing anterior cruciate ligament (ACL) injuries remains inconsistently reported in the literature.
Hypothesis/purpose: Systematically review the literature and perform a meta-analysis to statistically evaluate the accuracy of US in diagnosing ACL tears.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!