Pulmonary haemosiderosis (PH) results from recurrent bleeding into alveolar spaces and interstitial lung tissue. If untreated, fibrosis and restrictive lung disease will develop and may lead to death. A distinction can be made between primary and secondary pulmonary haemosiderosis as a manifestation of auto-immune small vessel vasculitides, coagulation disorders or diseases with increased venous pressure. Interestingly, in some cases of 'idiopathic' PH, exposure to moulds and van Willebrand's disease may contribute to the pathogenesis. Haemosiderosis usually begins with haematemesis. Anaemia, alveolar infiltrates on chest x ray and siderophages in broncho-alveolar lavage fluid are diagnostic factors. Immunosuppressive treatment has improved the prognosis in recent years.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.prrv.2005.11.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A positive-sense single-stranded RNA virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused the coronavirus disease 2019 (COVID-19) pandemic that devastated the world. While this is a respiratory virus, one feature of the SARS-CoV-2 infection was recognized to cause pathogenesis of other organs. Because the membrane fusion protein of SARS-CoV-2, the spike protein, binds to its major host cell receptor angiotensin-converting enzyme 2 (ACE2) that regulates a critical mediator of cardiovascular diseases, angiotensin II, COVID-19 is largely associated with vascular pathologies.
View Article and Find Full Text PDFReduced number of alveoli after birth in rats exposed to iron in utero.
Pediatr Int
December 2024
Center for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan.
Background: Clinical studies have shown that diffuse chorioamniotic hemosiderosis (DCH) is a risk factor for bronchopulmonary dysplasia (BPD). However, the details of the underlying mechanism are unknown. We focused on iron, one of the blood components that diffuses within the amniotic cavity in DCH.
View Article and Find Full Text PDFChildhood interstitial lung disease survivors in adulthood: a European collaborative study.
Eur Respir J
December 2024
2nd Pulmonary Medicine Department, General University Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Greece.
Background: Interstitial lung disease (ILD) is rarer in children (chILD) than adults, but with increasing diagnostic awareness, more cases are being discovered. chILD prognosis is often poor, but increasing numbers are now surviving into adulthood.
Aim: To characterize chILD-survivors and identify their impact on adult-ILD centers.
Toxicity study of Stachybotrys chartarum (CASRN 67892-26-6) administered by inhalation to B6C3F1/N mice.
Toxic Rep Ser
October 2024
Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Stachybotrys chartarum, also known as "black mold," is a cellulolytic saprophyte with a worldwide distribution. Public concern for potential illnesses associated with water-damaged indoor environments has been heightened since the report of pediatric acute idiopathic pulmonary hemorrhage/hemosiderosis cases in the United States and following recent natural disasters. Although mycotoxicosis and pulmonary immunological endpoints have been previously examined, the systemic toxicity following subchronic inhalation of viable S.
View Article and Find Full Text PDFClinical features and risk factors for recurrence of idiopathic pulmonary hemosiderosis in children.
BMC Pulm Med
September 2024
Division of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Article Synopsis
- - The study reviewed the clinical features, treatment response, and outcomes of pediatric idiopathic pulmonary hemosiderosis (IPH), aiming to identify recurrence risk factors for better early diagnosis and treatment.
- - Among 32 children studied, common initial symptoms were anemia (90.6%), cough (75%), and hemoptysis (56.2%), with a median diagnosis delay of 5 months; many experienced remission but 19 had relapses mainly due to respiratory infections and medication issues.
- - Key findings indicated that children with a history of allergies were more likely to relapse, and while high-dose corticosteroids were used, they did not significantly lower recurrence rates; cough and anemia were identified as the most prevalent symptoms.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!