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Integration of ATAC-Seq and RNA-Seq Reveals the Role of in Red Light-Induced Fruit Ripening in Strawberry.
Int J Mol Sci
January 2025
Institute of Pomology, Jiangsu Academy of Agricultural Sciences/Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement/Jiangsu Province Engineering Research Center of Modern Strawberry Industry/Zhongshan Biological Breeding Laboratory, 50 Zhonglin Road, Nanjing 210014, China.
Light is an important environmental factor affecting the ripening and quality of strawberry fruit. Previous studies have shown that red light treatment can promote strawberry ripening. Gene expression is closely associated with chromatin openness, and changes in chromatin accessibility are crucial for the binding of transcription factors to downstream regulatory sequences.
View Article and Find Full Text PDFMetabolic profiling of meningioma reveals novel subgroup-specific biologic insights and outcome dependencies.
Neuro Oncol
January 2025
MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada.
Background: Our group and others have recently identified four molecular groups of meningioma, with unique underlying biology and outcomes. The relevance of group-specific metabolite profiles (particularly among hypermetabolic tumours), has not been explored.
Methods: We performed untargeted metabolic profiling of meningiomas representing each molecular group and WHO grade.
Vitamin D binding protein genetic isoforms, serum vitamin D, and cancer risk in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
PLoS One
December 2024
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, United States of America.
Associations between vitamin D biochemical status and cancer may be modified by vitamin D binding protein isoforms which are encoded by GC (group-specific component). We examined interactions between serum 25-hydroxyvitamin D [25(OH)D], the Gc isoforms Gc1-1, Gc1-2, and Gc2-2, and cancer risk within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort based on 3,795 cases and 3,856 controls. Multivariable-adjusted logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) of cancer risk according to 25(OH)D quantiles, stratified by Gc isoform.
View Article and Find Full Text PDFEconomic effects of priority setting in healthcare: a scoping review of current evidence.
BMJ Open
November 2024
Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Objectives: Study objective was to map the current literature on the economic effects of priority setting at the system level in healthcare.
Design: The study was conducted as a scoping review.
Data Sources: Scopus electronic database was searched in June 2023.
Production of GcMAF with Anti-Inflammatory Properties and Its Effect on Models of Induced Arthritis in Mice and Cystitis in Rats.
Curr Issues Mol Biol
September 2024
Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Vitamin D transporter (DBP) is a multifunctional protein. Site-specific deglycosylation results in its conversion to group-specific component protein-derived macrophage activating factor (GcMAF), which is capable of activating macrophages. It has been shown that depending on precursor conversion conditions, the resulting GcMAF activates mouse peritoneal macrophages towards synthesis of either pro- (IL-1β, TNF-α-M1 phenotype) or anti-inflammatory (TGF-β, IL-10-M2 phenotype) cytokines.
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