AI Article Synopsis
- Digoxin-like inhibitors of Na+,K(+)-ATPase have been linked to various health problems during the perinatal period.
- A study extracted a substance called endogenous digoxin-like immunoreactive substance (DLIS) from nine organs of a 24-week-old fetus, showing that it is widely distributed in fetal tissues, particularly high in the gut and adrenal glands.
- The findings suggest a possible correlation between high levels of DLIS and the inhibition of Na+,K(+)-ATPase, supporting the idea that this substance may originate from the fetus itself.
Article Abstract
Digoxin-like inhibitors of Na+,K(+)-ATPase have been implicated in several pathophysiological problems in the perinatal period. Aqueous endogenous digoxin-like immunoreactive substance (DLIS) was extracted from 9 different organs of a 24-week-old human fetus whose mother died after paraquat poisoning. The results indicate that this endogenous DLIS has a wide distribution in fetal tissues. The highest levels were found in gut and adrenals, and there was a correlation between these high levels and the inhibition of Na+,K(+)-ATPase. The hypothesis that DLIS originated in the fetus is of particular relevance.
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| http://dx.doi.org/10.1159/000243335 | DOI Listing |
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