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Trends in human parainfluenza virus in Scotland before and after the peak of the COVID-19 pandemic, January 2017 to October 2023.
Euro Surveill
January 2025
Respiratory Team, Clinical and Protecting Health Directorate, Public Health Scotland, Glasgow, United Kingdom.
BackgroundHuman parainfluenza viruses (HPIV) commonly cause upper respiratory tract infections, with potential for severe lower respiratory complications. Understanding seasonal increases informs strategies to prevent HPIV spreading.AimWe examined the impact of COVID-19 on HPIV epidemiological and clinical patterns in Scotland using non-sentinel and sentinel surveillance data.
View Article and Find Full Text PDFThe structural basis of protective and nonprotective human monoclonal antibodies targeting the parainfluenza virus type 3 hemagglutinin-neuraminidase.
Nat Commun
December 2024
Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Parainfluenza virus 3 (PIV3) infection poses a substantial risk to vulnerable groups including infants, the elderly, and immunocompromised individuals, and lacks effective treatments or vaccines. This study focuses on targeting the hemagglutinin-neuraminidase (HN) protein, a structural glycoprotein of PIV3 critical for viral infection and egress. With the objective of targeting these activities of HN, we identified eight neutralizing human monoclonal antibodies (mAbs) with potent effects on viral neutralization, cell-cell fusion inhibition, and complement deposition.
View Article and Find Full Text PDFMycoplasma ovipneumoniae identified as the main aetiological agent of respiratory disease in goats from a case-control study in Savannakhet province of Lao PDR.
Vet Microbiol
February 2025
School of Environmental and Rural Science, University of New England, Armidale, NSW, Australia.
Clinical signs of respiratory disease are common in Lao goats. To identify the causative agents involved in this clinical syndrome, a matched case-control study was conducted across 70 smallholder goat holdings in Savannakhet province. Fifty paired nasal swab samples were collected from goats with respiratory signs (cases) and unaffected (control) goats from 27 goat holdings.
View Article and Find Full Text PDFEpidemiological, Clinical, and Genomic Traits of PIV in Hospitalized Children After the COVID-19 Pandemic in Wuhan, China.
J Med Virol
December 2024
Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Human parainfluenza virus (PIV) is a main cause of acute lower respiratory tract infections (ALRTIs), which contributes to childrens' mortality worldwide; however, the epidemiology of PIVs following the SARS-CoV-2 pandemic is still not clarified, and poses risks of potential outbreaks. Herein, we conducted a retrospective observational study from September 26, 2020 to September 30, 2023 to assess PIV epidemiology in Wuhan, China, as well as the clinical characteristics of PIV infections. In total, 14,065 inpatients with ALRTIs were enrolled, of which 936 were identified to have PIV infection.
View Article and Find Full Text PDFUnveiling the hidden threats: a review of pathogen diversity and public health risks from bats, rodents, and non-human primates in Zambia (1990-2022).
Front Public Health
December 2024
Macha Research Trust, Choma, Zambia.
Article Synopsis
- Researchers have identified a rising trend of zoonotic diseases in Zambia, a key transport hub in Southern Africa, where numerous pathogens from bats, rodents, and non-human primates pose public health risks.
- A review of studies from 1990 to 2022 found that viruses were the most reported pathogens, with notable threats including Ebola, Marburg, and Hantavirus, though many findings are based on short-term investigations.
- The study highlights a significant lack of surveillance for these diseases in humans and emphasizes the urgent need for improved monitoring and preventive measures to mitigate emerging infectious risks in the region.
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