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Mechanistic Understanding of Differences in Cytotoxicity Induced by Food Additives Methyleugenol and Methylisoeugenol.
J Agric Food Chem
January 2025
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.
Methyleugenol (ME) has been classified as a "group 2B carcinogen" by IARC. Its positional isomer methylisoeugenol (MIE) has been considered to be of "generally recognized as safe'' status by FDA. ME was more cytotoxic than MIE in cultured mouse primary hepatocytes.
View Article and Find Full Text PDFUnderstanding the Effects of Three Carbohydrate Feeds on the Health of Apis mellifera by Transcriptome Analysis.
Arch Insect Biochem Physiol
January 2025
Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
At present, there is no clear consensus on the impact of carbohydrate feeds on bee colony health, and comprehensive research and evaluation in this context is lacking. To comprehensively and objectively examine the health status of honeybees after consuming those carbohydrates from multiple perspectives, experimental techniques, including high-throughput sequencing of the transcriptome, proboscis extension reflex (PER), and measuring bee growth parameters were employed. This study showed that compared with honey, feeding high fructose syrup (HFS) resulted in a decrease in the survival rate and body weight of bees, while sucrose decreased the learning and memory ability of bees.
View Article and Find Full Text PDFSalvicsite A-C: Three Seco-Norabietane Diterpenoids Including an Unusual Tetracyclic Skeleton from Diels f. Stib.
J Org Chem
January 2025
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Three seco-norabietane diterpenoids, salvicsites A-C (-), along with two known compounds, were isolated from the roots and rhizomes of Diels f. Stib. Salvicsite A () represents an unprecedented structural combination, featuring an eight-membered α-methyl-α,β-unsaturated lactone ring and a five-membered α,β-unsaturated lactone ring, based on a 6/6/5/8 ring system.
View Article and Find Full Text PDFEffects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes.
Langmuir
January 2025
Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115, United States.
We performed all-atom and coarse-grained simulations of lipid bilayer mixtures of the unsaturated lipid DOPC, with saturated lipids having the same 18-carbon acyl tails and different headgroups, to understand their mechanical properties. The secondary lipids were DSPG, DSPA, DSPS, DSPC, and DSPE. The DOPC:DSPG system with 65:35 molar ratio was the softest, with area compressibility modulus ∼ 22% smaller than the pure DOPC value.
View Article and Find Full Text PDFAssociations between dietary fatty acids and kidney stones.
Sci Rep
January 2025
Department of Urology, The Affiliated Second Hospital, Hengyang Medical school, University of South China, Hengyang, 421009, China.
Kidney stones represent a significant global health challenge, with dietary habits playing a crucial role in their formation. This study investigates the association between dietary fatty acid intake-specifically saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA)-and the prevalence of kidney stones in a U.S.
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