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The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.
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| http://dx.doi.org/10.1016/j.canlet.2005.12.032 | DOI Listing |
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Article Synopsis
- Scientists found a specific gene variant called SPRY4 in women who have trouble getting pregnant, which could help explain some cases of infertility.
- They studied how this gene works in the body and found it's really important for female reproductive health.
- Before this study, no one had linked this gene to female fertility issues, so their discovery could lead to better understanding and treatments for infertility.
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