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Blood usage among orthopedic patients at the Rivers State University Teaching Hospital, Port Harcourt, Nigeria.
Niger Med J
January 2025
Department of Surgery, Rivers State University Teaching Hospital, Port Harcourt, Nigeria.
Background: Blood transfusion holds a significant place in the practice of surgery, including orthopaedic surgeries. The aim of this study was to evaluate the intraoperative use of blood and blood products among orthopaedic patients operated at the Rivers State University Teaching Hospital from January 2021 to December 2021, focusing on the demographics of patients, number and type of surgeries needing a blood transfusion, and the number of blood transfusions.
Methodology: A retrospective observational study was carried out at the operating theatre of a referral tertiary hospital using a designed proforma to extract data from the registers of operated orthopaedic patients.
Diabetes mellitus and peripheral artery disease.
Diabetol Int
January 2025
Department of Laboratory Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-Oka, Suita City, Osaka 565-0871 Japan.
Atherosclerotic peripheral artery disease (PAD), that is, arteriosclerosis obliterans, is pathologically rooted in atherosclerosis, similar to other cardiovascular diseases. In addition to smoking, hypertension, and dyslipidemia, diabetes mellitus is a major risk factor. People with diabetes mellitus have an elevated risk of developing PAD.
View Article and Find Full Text PDFImmunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets.
Front Immunol
January 2025
Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Background: Type 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. Immune cells, including T cells and monocytes, play a pivotal role in driving systemic inflammation in T2DM; however, the underlying single-cell mechanisms remain inadequately defined.
Methods: Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from 37 patients with T2DM and 11 healthy controls (HC) was conducted.
Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway.
Arch Endocrinol Metab
January 2025
Fuzhou First General Hospital Affiliated with Fujian Medical University Department of Endocrinology FuzhouFujian China Department of Endocrinology, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, China.
Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes.
View Article and Find Full Text PDFCognitive dysfunction in diabetes - the 'forgotten' diabetes complication: a narrative review.
Scand J Prim Health Care
January 2025
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Background: In addition to peripheral neuropathy of various kinds, diabetes can also cause central neuropathy, which among other things can manifest itself as premature cognitive dysfunction, often linked to vascular dysfunction. Although the link between diabetes and cognitive dysfunction was discovered more than 100 years ago and has important clinical implications, this diabetes complication remains relatively unknown. Recent years have seen research that has clarified cerebral insulin resistance and defective insulin signaling as examples of pathogenic factors behind this cognitive impairment in diabetes.
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