AI Article Synopsis
- The reaction involves dibromoacetic acid reacting with various aldehydes using samarium diiodide (SmI2) to produce (E)-alpha,beta-unsaturated carboxylic acids with high stereoselectivity.
- This process includes an elimination step that is also facilitated by samarium diiodide.
- A proposed mechanism is provided to explain how this transformation occurs.
Article Abstract
A promoted SmI2 direct reaction of dibromoacetic acid with different aldehydes, followed by an elimination reaction also promoted by samarium diiodide, affords (E)-alpha,beta-unsaturated carboxylic acids 2 with total stereoselectivity. A mechanism to explain this transformation is proposed.
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| http://dx.doi.org/10.1021/jo052236x | DOI Listing |
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