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Targeting Epigenetic Dysregulations in Head and Neck Squamous Cell Carcinoma.
J Dent Res
December 2024
Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.
Head and neck squamous cell carcinoma (HNSCC) is one of the deadliest human cancers, with the overall 5-year survival rate stagnating in recent decades due to the lack of innovative treatment approaches. Apart from the recently Food and Drug Administration-approved epidermal growth factor receptor inhibitor and immune checkpoint inhibitor, alternative therapeutic strategies that target epigenetic abnormalities, an emerging cancer hallmark, remain to be fully explored. A pathological epigenetic landscape, characterized by widespread reprogramming of chromatin modifications such as DNA methylation and histone modifications, which drives transcription deregulation and genome reorganization, has been extensively documented in numerous cancers, including HNSCC.
View Article and Find Full Text PDFGiant cell arteritis: update on pathogenesis and clinical implications.
Curr Opin Rheumatol
January 2025
Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
Purpose Of Review: Giant cell arteritis (GCA) is an age-related autoimmune disease with a complex pathogenesis that involves several pathogenic mechanisms. This review provides recent critical insights into novel aspects of GCA pathogenesis.
Recent Findings: The use of novel approaches, including multiomic techniques, has uncovered notable findings that broaden the understanding of GCA pathogenesis.
Assessing the initial impact of the Russian invasion on Ukrainian agriculture: Challenges, policy responses, and future prospects.
Heliyon
November 2024
Agricultural Economics and Policy Group, ETH Zurich, Sonneggstrasse, 33, Zurich, 8092, Switzerland.
The war in Ukraine has caused significant losses to the Ukrainian agricultural sector and threatened global food security. This study aims to comprehensively analyse the impact of the Russian invasion on Ukrainian agriculture in its initial phase, examine the responses of Ukrainian agricultural policy and outline key elements for the post-war development of the Ukrainian agricultural sector. Using a systematic approach that includes thorough data collection and analysis from official sources, the Ukrainian press, relevant legislation and statistical data, our study focuses on the first five months of the conflict, from February 24, 2022 to July 24, 2022, to identify the main challenges during this period.
View Article and Find Full Text PDFTYRO3 and EPHA2 Expression Are Dysregulated in Breast Cancer.
Cell Biochem Funct
September 2024
Keizo Asami Institute (iLIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Article Synopsis
- - Receptor tyrosine kinases (RTKs) play crucial roles in cell functions like growth and differentiation, and when their signaling is disrupted, it can lead to tumors and make treatments less effective.
- - This study analyzed gene expressions of specific RTKs (TAM, RON, EPHA2, and MET) in breast cancer tissues using qPCR, focusing on how these expressions relate to clinical data.
- - Findings suggest that the expression of TYRO3, MET, and EPHA2 is associated with factors like tumor subtype, patient age, and lifestyle choices such as smoking and obesity, indicating their potential significance in breast cancer.
Understanding Cytochrome P450 Enzyme Substrate Inhibition and Prospects for Elimination Strategies.
Chembiochem
November 2024
State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology, Jinan, Shandong, China.
Cytochrome P450 (CYP450) enzymes, which are widely distributed and pivotal in various biochemical reactions, catalyze diverse processes such as hydroxylation, epoxidation, dehydrogenation, dealkylation, nitrification, and bond formation. These enzymes have been applied in drug metabolism, antibiotic production, bioremediation, and fine chemical synthesis. Recent research revealed that CYP450 catalytic kinetics deviated from the classic Michaelis-Menten model.
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