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Monitoring nap deprivation-induced fatigue using fNIRS and deep learning.
Cogn Neurodyn
December 2025
Faculty of Psychology, Naval Medical University (Second Military Medical University), No. 800 Xiangyin Road, Yangpu District, Shanghai, 200433 China.
Fatigue-induced incidents in transportation, aerospace, military, and other areas have been on the rise, posing a threat to human life and safety. The determination of fatigue states holds significant importance, especially through reliable and conveniently available physiological indicators. Here, a portable custom-built fNIRS system was used to monitor the fatigue state caused by nap deprivation.
View Article and Find Full Text PDFLayered Double Hydroxide Nanosheets Incorporated Hierarchical Hydrogen Bonding Polymer Networks for Transparent and Fire-Proof Ceramizable Coatings.
Nanomicro Lett
January 2025
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen, 361000, People's Republic of China.
In recent decades, annual urban fire incidents, including those involving ancient wooden buildings burned, transportation, and solar panels, have increased, leading to significant loss of human life and property. Addressing this issue without altering the surface morphology or interfering with optical behavior of flammable materials poses a substantial challenge. Herein, we present a transparent, low thickness, ceramifiable nanosystem coating composed of a highly adhesive base (poly(SSS-co-HEMA)), nanoscale layered double hydroxide sheets as ceramic precursors, and supramolecular melamine di-borate as an accelerator.
View Article and Find Full Text PDFQuality of Life Study in Chronic Diseases: More Needed Than Ever.
Acta Med Indones
October 2024
School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia - St Carolus Hospital, Jakarta, Indonesia.
Numerous thyroid diseases can impact patients' lives, one of which is Graves' ophthalmopathy (GO). Graves' ophthalmopathy is a progressive thyroid-related disease that causes eye symptoms due to an autoimmune reaction targeting thyrotropin/thyroid stimulating hormone (TSH) receptors in the orbital space. This condition can be easily recognized by the patient, including exophthalmos, pain, swelling, double vision, and impaired vision.
View Article and Find Full Text PDF1-Year real-world outcomes of faricimab in previously treated neovascular age-related macular degeneration.
Eye (Lond)
January 2025
Maidstone Hospital Eye Department, Hermitage Lane, Maidstone, UK.
Background And Objectives: Faricimab, a bispecific antibody targeting VEGF-A and angiopoietin-2, has shown promise in treating neovascular age-related macular degeneration (nAMD). This study evaluates 1-year outcomes of faricimab in treatment-experienced nAMD patients.
Methods: This single-centre retrospective cohort study included patients previously treated for nAMD who switched to faricimab between November 2022 and March 2024.
High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p.
Nat Commun
January 2025
Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA.
DEAD-box RNA-dependent ATPases are ubiquitous in all domains of life where they bind and remodel RNA and RNA-protein complexes. DEAD-box ATPases with helicase activity unwind RNA duplexes by local opening of helical regions without directional movement through the duplexes and some of these enzymes, including Ded1p from Saccharomyces cerevisiae, oligomerize to effectively unwind RNA duplexes. Whether and how DEAD-box helicases coordinate oligomerization and unwinding is not known and it is unclear how many base pairs are actively opened.
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