AI Article Synopsis
- The study assessed the effects of an octapeptide called A 6 on reducing choroidal neovascularization (CNV) induced by laser in monkeys.
- Twenty female cynomolgus monkeys were divided into groups receiving either weekly or monthly A 6 injections, and their CNV levels were monitored over four weeks.
- Results showed that monthly injections led to a significant 71% reduction in CNV compared to controls, while weekly injections saw a smaller 35% reduction; both methods showed no signs of toxicity, indicating A 6's potential for treating similar conditions in humans.
Article Abstract
Purpose: To evaluate the inhibitory effects of a urokinase-derived octapeptide, A 6, on laser-induced choroidal neovascularization (CNV) in monkeys.
Methods: Twenty female cynomolgus monkeys were randomly grouped into weekly or monthly A 6 treatment groups, each consisting of 10 animals. CNV was induced in both eyes by perimacular laser treatment. In each right eye, a single 22.25-mg A 6 dose (monthly group) or 4 22.25-mg A 6 doses each week (weekly group) were given by intravitreal injections. Each left eye received phosphate buffer on the same schedule. Monkeys were observed for 4 weeks by ophthalmic examinations, color photography, and fluorescein angiography.
Results: Weekly treated eyes had a 35% reduction of CNV compared with controls (P = 0.23). In contrast, monthly treated eye had a 71% reduction of CNV compared with controls (P = 0.0009). There was no evidence of toxicity at both clinical and pathologic examinations.
Conclusions: Intravitreal A 6 injections effectively inhibited CNV in cynomolgus monkeys without evidence of toxicity. The overall reduction in CNV was greater for monthly treated eyes than for weekly treated eyes. This study suggests that A 6 has promise as a local antiangiogenic treatment of CNV. Further work is indicated to evaluate the potential role of A 6 in therapy for human CNV associated with age-related macular degeneration.
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| http://dx.doi.org/10.1097/00006982-200602000-00014 | DOI Listing |
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