AI Article Synopsis
- The SOS chromotest was used to study and detect antimutagens by inducing SOS response in bacteria with various mutagens like UV light and specific chemicals.
- Antimutagens such as L-ascorbic acid, glutathione, and others were tested for their ability to inhibit mutagen effects either at the same time or after treatment.
- Results demonstrated that the SOS chromotest is an effective method for identifying substances that can counteract the effects of mutagens.
Article Abstract
The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4-nitroquinoline N-oxide (4NQO), N-methyl-N'-nitro-N-nitroso-guanidine (MNNG), or benzo[a]pyrene (B[a]p). The inhibitory effects of L-ascorbic acid, glutathione, vanillin, 5-fluorouracil (5-FU), 5-chlorouracil (5-CU), cobaltous chloride, sodium selenite and sodium arsenite, which are known as antimutagens, were investigated with their addition either simultaneously or post treatment time. It became clear that the SOS chromotest was very useful for the detection of antimutagens.
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| http://dx.doi.org/10.1002/em.2850170407 | DOI Listing |
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