AI Article Synopsis
- The study investigated the effectiveness of yogurt in treating vaginal candidosis using a mouse model specifically designed for estrogen-dependent vaginal candidosis (EDVC).
- Yogurt-treated mice showed significantly lower levels of Candida albicans infection compared to untreated EDVC mice, while metronidazole-treated mice had persistent colonization of the yeast.
- Results suggest that Lactobacillus from yogurt may help inhibit C. albicans growth, while antibiotics like metronidazole could contribute to the development of vaginal candidosis.
Article Abstract
The efficacy of yogurt treatment against vaginal candidosis (VC) was examined using an oestrogen-dependent vaginal candidosis (EDVC) murine model. The EDVC mouse model was constructed by inoculating mice with viable Candida albicans cells under pseudo-oestrus conditions. Vaginal fungal burden in the various mouse groups was evaluated at several time points following the induction of VC. Untreated and yogurt-treated naïve mice exhibited background levels of VC (<6000 CFU per mouse). Candida albicans colonisation in untreated EDVC mice was significantly higher (P < 0.05) than that in yogurt-treated EDVC mice at days 20-30. Metronidazole-treated naïve mice developed persistent C. albicans vaginal colonisation at significantly lower levels (P < 0.05) than that in untreated or metronidazole-treated EDVC mice. Lactobacillus was only detected in the reproductive tracts of yogurt-treated naïve and EDVC mice. These findings suggest that the presence of Lactobacillus in the reproductive tract can suppress C. albicans growth and the antibiotics may predispose to VC.
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| http://dx.doi.org/10.1111/j.1439-0507.2006.01200.x | DOI Listing |
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