Objective: To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.
Methods: ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing.
Results: A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05).
Conclusion: Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.
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