Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2006.01.085 | DOI Listing |
Publication Analysis
Top Keywords
substituted coumarins
4
coumarins potent
4
potent 5-lipoxygenase
4
5-lipoxygenase inhibitors
4
inhibitors leukotriene
4
leukotriene biosynthesis
4
biosynthesis inhibitors
4
inhibitors potential
4
potential therapeutic
4
therapeutic agents
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!