Fluorescent analogs were synthesized of the potent PI 3-kinase inhibitors, wortmannin and demethoxyviridin. The esterification of 11-deacetylwortmannin, 17-hydroxywortmannin, and demethoxyviridin with the fluorescent carboxylic acids NBD-sarcosine and 7-dimethylaminocoumarin-4-acetic acid generated six novel fluorescent esters. Potent inhibition of PI 3-kinase-alpha was observed for the derivatives of 11-desacetylwortmannin and demethoxyviridin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2006.01.091 | DOI Listing |
Publication Analysis
Top Keywords
wortmannin demethoxyviridin
8
synthesis fluorescent
4
fluorescent derivatives
4
derivatives wortmannin
4
demethoxyviridin
4
demethoxyviridin probes
4
probes phosphatidylinositol
4
phosphatidylinositol 3-kinase
4
3-kinase fluorescent
4
fluorescent analogs
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!