Three rapid, simple and accurate analytical methods for the determination of citalopram in tablets were developed. The capillary zone electrophoresis (CZE) method was carried out using fused silica capillary with 67 mM phosphate buffer pH 7.0 as the background electrolyte, 30 kV of separation voltage and UV detection at 239 nm. The direct spectrophotometric method was performed by measuring the absorbance at the wavelength of 239 nm and derivative spectrophotometric assay was carried out by measuring the value of the second derivative of the spectrum at 210 nm. The linearity range for CZE method was 5-50 microg/mL and for both spectrophotometric methods was 2-12 microg/mL. The recovery in CZE was between 98.6 and 102.4%, in the direct spectrophotometry between 95.0 and 98.0% and in derivative spectrophotometry between 97.6 and 103.3%. The RSD values were between 1.36 and 2.30%, 1.80 and 2.70%, 1.52 and 2.68%, respectively.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Impact of CYP2C19 Phenotype on Escitalopram Response in Geriatrics: Based on Physiologically-Based Pharmacokinetic Modeling and Clinical Observation.
Clin Pharmacol Ther
December 2024
College of Pharmacy, CHA University, Seongnam-si, Gyeonggi-do, South Korea.
Escitalopram is commonly prescribed for depressive and anxiety disorders in elderly patients, who often show variable drug responses and face higher risks of side effects due to age-related changes in organ function. The CYP2C19 polymorphism may further affect escitalopram pharmacokinetics in elderly patients, complicating dose optimization for this group. Previous pharmacogenetic studies examining the impact of CYP2C19 phenotype on escitalopram treatment outcomes have primarily focused on younger adults, leaving a gap in understanding its effects on the elderly.
View Article and Find Full Text PDFTest-Retest Reliability of Two Computationally-Characterised Affective Bias Tasks.
Comput Psychiatr
December 2024
Anxiety Lab, Neuroscience and Mental Health Group, Institute of Cognitive Neuroscience, University College London, UK.
Affective biases are commonly seen in disorders such as depression and anxiety, where individuals may show attention towards and preferential processing of negative or threatening stimuli. Affective biases have been shown to change with effective intervention: randomized controlled trials into these biases and the mechanisms that underpin them may allow greater understanding of how interventions can be improved and their success be maximized. For such trials to be informative, we must have reliable ways of measuring affective bias over time, so we can detect how and whether they are altered by interventions: the test-retest reliability of our measures puts an upper bound on our ability to detect any changes.
View Article and Find Full Text PDFDepression is Associated with Treatment Response Trajectories in Adults with Prolonged Grief Disorder: A Machine Learning Analysis.
medRxiv
December 2024
Department of Psychiatry, New York University Grossman School of Medicine, New York, New York.
Unlabelled: Although evidence-based treatments for Prolonged Grief Disorder (PGD) exist, pretreatment characteristics associated with differential improvement trajectories have not been identified. To identify clinical factors relevant to optimizing PGD treatment outcomes, we used unsupervised and supervised machine learning to study treatment effects from a double-blinded, placebo-controlled, randomized clinical trial. Participants were randomized into four treatment groups for 20 weeks: citalopram with grief-informed clinical management, citalopram with prolonged grief disorder therapy (PGDT), pill placebo with PGDT, or pill placebo with clinical management.
View Article and Find Full Text PDFRisk of congenital anomalies associated with psychotropic medications: a review of neonatal reports in the FDA adverse event reporting System (FAERS).
Arch Womens Ment Health
December 2024
College of Pharmacy, Jinan University, Guangzhou, Guangdong, China.
Purpose: This study investigates the potential association between commonly prescribed psychotropic medications, such as Atypical Antipsychotics (AAs), Selective Serotonin Reuptake Inhibitors (SSRIs), and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), and congenital anomalies in newborns. The analysis uses data from the Food and Drug Administration Adverse Event Reporting System (FAERS).
Methods: Spontaneously reported cases of congenital anomalies in newborns (under 28 days old) were extracted from the FAERS database, covering January 2004 to June 2023.
Investigation of Pharmacokinetic and Pharmacodynamic Interactions between Citalopram and Duloxetine: An Integrated Analytical, Computational, Behavioral, and Biochemical Approach.
ACS Pharmacol Transl Sci
December 2024
School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Despite the prevalent utilization of antidepressant combinations in clinical settings, concerns persist regarding heightened side effects and potential drug-drug interactions (DDI). In response, this study investigates the interaction between citalopram (CIT) and duloxetine (DUL) using a multifaceted approach encompassing analytical, computational, behavioral, and biochemical techniques. Notably, the absence of published analytical methods tailored for studying antidepressant interactions underscores the novelty of our endeavor.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!