In the January 13 issue of Cell, Coyne and Bergelson describe an "Open sesame!" strategy developed by coxsackieviruses to invade the organism through the intestinal epithelium. The strategy involves coopting intrinsic signaling abilities of the apical GPI-anchored protein DAF to open the tight junction barrier, gain access to the primary receptor CAR, and activate virus internalization by a caveolin-dependent pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.devcel.2006.01.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety assessment of turmeric-boswellia-sesame formulation in healthy adult volunteers: An open-label prospective study.
Adv Clin Exp Med
January 2025
Department of Food Science and Technology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Colombo, Sri Lanka.
Background: Turmeric and boswellia supplements have gained popularity for their anti-inflammatory and antioxidant properties. It is important to critically assess the safety of such supplements for prolonged use.
Objectives: To assess the safety and tolerability of turmeric-boswellia-sesame oil formulation (TBSF) in healthy human volunteers.
Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway.
Drug Dev Res
December 2024
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Plant-based components have helped generate novel lead molecules and scaffolds for anxiety research in psychopharmacology. The present study examined the anxiolytic properties of sesamol (SES), a phenolic lignan derived from Sesamum indicum, employing both in vivo and computational methods to understand its mechanisms of action. In this experiment, adult Swiss albino mice received various doses of SES (25 and 50 mg/kg, p.
View Article and Find Full Text PDFFormulation of a High-Quality Cold-Pressed Vegetable Oil (Virgin) Based on a Blend of Four Oilseeds.
Foods
October 2024
Regional Agricultural Research Center of Meknes, National Institute of Agricultural Research, Avenue Ennasr, P.O. Box 415, Rabat 10090, Morocco.
Vegetable oils are crucial for the human diet, providing energy and essential fatty acids. This study investigates the formulation of a high-quality cold-pressed vegetable oil blend from rapeseed, sunflower, sesame, and safflower, chosen for their agronomic benefits, cost-effectiveness, and reduced environmental impact. For the first time, this study is carried out in order to enhance the nutritional profile of these blend oils compared to commercial oils.
View Article and Find Full Text PDFOgden R. Lindsley: I Followed the Idea of the Missoula Smokejumpers.
Behav Anal Pract
September 2024
Behavior Development Solutions, Bonita Springs, FL USA.
In 1990, Ogden R. Lindsley served as guest faculty for Ohio State University's Teleconference on applied behavior analysis. He captivated students and faculty with tales of his personal journey from experiences during World War II to studying under B.
View Article and Find Full Text PDFChemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system.
Commun Biol
October 2024
Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Solnavägen 9, S-17165, Stockholm, Sweden.
Article Synopsis
- Scientists are studying drugs called ISR inhibitors to see if they can help with diseases by lowering stress responses in cells.
- However, stopping this stress response might also harm the cell's ability to maintain healthy proteins.
- In their experiments, a compound called ISRIB was found to mess up the process that normally breaks down damaged proteins in the cell’s fluid area, leading to a buildup of defective proteins.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!