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Current Trends in HIV Infection in the Republic of Crimea.
Viruses
October 2024
Federal State Budget Institution "National Research Center for Epidemiology and Microbiology Named After the Honorary Academician N.F. Gamaleya", Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Article Synopsis
- * There was an increase in the coverage of HIV testing and antiretroviral therapy, with 81% of patients achieving a suppressed viral load by 2023.
- * Demographic analysis showed that most new HIV cases were among men, with fewer cases from injection drug use and an increase in heterosexual transmission; the median age of patients also rose, revealing significant differences in CD4 counts based on gender and infection route.
Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease.
PLoS One
November 2024
Takeda Development Center Americas, Inc., San Diego, California, United States of America.
Induction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other β-hemoglobinopathies. To identify targets and target-modulating small molecules that enhance HbF expression, we engineered a human umbilical-derived erythroid progenitor reporter cell line (HUDEP2_HBG1_HiBiT) by genetically tagging a HiBiT peptide to the carboxyl (C)-terminus of the endogenous HBG1 gene locus, which codes for γ-globin protein, a component of HbF. Employing this reporter cell line, we performed a chemogenomic screen of approximately 5000 compounds annotated with known targets or mechanisms that have achieved clinical stage or approval by the US Food and Drug Administration (FDA).
View Article and Find Full Text PDFThe Transmission Route and Selection Pressure in HCV Subtype 3a and 3b Chinese Infections: Evolutionary Kinetics and Selective Force Analysis.
Viruses
July 2022
Institute of Clinical Blood Transfusion, Guangzhou Blood Center, Guangzhou 510095, China.
Hepatitis C virus (HCV) genotype 3 (GT-3) represents 22-30% of all infections and is the second most common genotype among all HCV genotypes. It has two main subtypes, GT-3a and GT-3b, that present epidemiological differences in transmission groups. This report generated 56 GT-3a and 64 GT-3b whole-genome sequences to conduct an evolutionary kinetics and selective force analysis with reference sequences from various countries.
View Article and Find Full Text PDFRehabilitative interventions for ischaemic digital ulcers, pain, and hand functioning in systemic sclerosis: a prospective before-after study.
BMC Musculoskelet Disord
March 2022
Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Palermo, Italy.
Article Synopsis
- Systemic sclerosis (SSc) is a rare disease that affects the skin and internal organs, often resulting in painful ischemic digital ulcers (IDUs) on the hands.
- A study was conducted with 20 SSc patients to assess the effectiveness of a rehabilitation protocol using ultrasound therapy combined with manual therapy for treating IDUs.
- Results showed significant improvements in ulcer healing, pain reduction, and hand function, with no reported side effects, suggesting that this combined approach is a safe and beneficial option for managing IDUs in SSc patients.
Self-reported hepatitis C(HCV) testing among people living with human immunodeficiency virus (PLWH).
Heliyon
August 2021
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, PO Box 100231, Gainesville, FL, 32610, USA.
Objective: We aimed to identify disparities in self-reported HCV testing among persons living with HIV (PLWH) in Florida.
Methods: We utilized a cross-sectional study of 646 PLWH from the Florida Cohort study's baseline survey. Our analysis included chi-squared tests and logistic regression.
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