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Aims: Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction following myocardial infarction (MI) remains uncertain. This study aimed at understanding the effects of Sac/Val on regional function after MI.
View Article and Find Full Text PDFTargeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer.
Nat Commun
October 2024
Department of Biosciences, University of Oslo, Oslo, Norway.
Unfolded protein response (UPR) is a central stress response pathway that is hijacked by tumor cells for their survival. Here, we find that IRE1α signaling, one of the canonical UPR arms, is increased in prostate cancer (PCa) patient tumors. Genetic or small molecule inhibition of IRE1α in syngeneic mouse PCa models and an orthotopic model decreases tumor growth.
View Article and Find Full Text PDFResting membrane potential and intracellular [Na] at rest, during fatigue and during recovery in rat soleus muscle fibres in situ.
J Physiol
July 2024
Institute for Experimental Medical Research, University of Oslo and Oslo University Hospital, Oslo, Norway.
Large trans-sarcolemmal ionic shifts occur with fatiguing exercise or stimulation of isolated muscles. However, it is unknown how resting membrane potential (E) and intracellular sodium concentration ([Na]) change with repeated contractions in living mammals. We investigated (i) whether [Na] (peak, kinetics) can reveal changes of Na-K pump activity during brief or fatiguing stimulation and (ii) how resting E and [Na] change during fatigue and recovery of rat soleus muscle in situ.
View Article and Find Full Text PDFInteraction of T-cell-specific adapter protein with Src- and Tec-family kinases.
Scand J Immunol
May 2024
Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Adapter proteins are flexible and dynamic modulators of cellular signalling that are important for immune cell function. One of these, the T-cell-specific adapter protein (TSAd), interacts with the non-receptor tyrosine kinases Src and Lck of the Src family kinases (SFKs) and Itk of the Tec family kinases (TFKs). Three tyrosine residues in the TSAd C-terminus are phosphorylated by Lck and serve as docking sites for the Src homology 2 (SH2) domains of Src and Lck.
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