Multifunctional hyperbranched polyether polyols bearing protective poly(ethylene glycol) (PEG) chains with or without the folate targeting ligand at their end have been prepared. Solubilization in these polymers of a fluorescent probe, pyrene, and an anticancer drug, tamoxifen, was physicochemically investigated. It was found that PEG chains attached at the surface of these hyperbranched polymers, in addition to their well-established protective role, enhance the encapsulation efficiency of the polymers. The release of pyrene and tamoxifen observed upon addition of sodium chloride is, in most of the cases, significant only at concentrations exceeding the physiological extracellular concentration. Thus, a significant amount of the probe or drug remains solubilized inside the carriers, which is an encouraging result if the polymers are to be used for drug delivery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mabi.200500181 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hyperbranched polyester amide/polyethersulphone mixed matrix nanofiltration membranes for contaminant rejection.
RSC Adv
January 2025
Packing and Packaging Materials Department, Institute of Chemical Industries Research, National Research Centre 33 El Behooth St., Dokki Giza Egypt +20 2 33371718.
Nanofiltration (NF) separation technology is a low-pressure filtration process, which is highly efficient and environmentally friendly. As a result, it has found wide application in water treatment. This work describes the preparation of flat sheet membranes the phase inversion method using blends of hyperbranched polyester amide (PEA) and polyether sulphone (PES) in definite ratios.
View Article and Find Full Text PDFBiocompatibility and Endothelial Permeability of Branched Polyglycidols Generated by Ring-Opening Polymerization of Glycidol with B(CF) under Dry and Wet Conditions.
Biomacromolecules
June 2024
Donostia International Physics Center (DIPC), Paseo Manuel Lardizábal 4, Donostia-San Sebastián, 20018, Spain.
Polyglycidol or polyglycerol (PG), a polyether widely used in biomedical applications, has not been extensively studied in its branched cyclic form (PG), despite extensive research on hyperbranched PG (HPG). This study explores the biomedical promise of PG, particularly its ability to cross the blood-brain barrier (BBB). We evaluate biocompatibility, endothelial permeability, and formation of branched linear PG (PG) as topological impurities in the presence of water.
View Article and Find Full Text PDFEfficient Demulsification Performance of Emulsified Condensate Oil by Hyperbranched Low-Temperature Demulsifiers.
Molecules
November 2023
Huabei Oilfield Company, China National Petroleum Corporation, Renqiu 062552, China.
Focusing on the problem of poor demulsification performance of light crude oil emulsions in low-permeability oilfields at low temperatures, the composition of the emulsion samples, clay particle size distribution, and the viscosity-temperature relationship curve of samples were analyzed. Based on the results of emulsion composition analysis and characteristics, the bottle test method was used to analyze the demulsifying effect of different commercial types of demulsifiers, revealing the demulsification mechanism. The field tests confirm the demulsification capabilities of Polyoxyethylene polyoxypropylene quaternized polyoxyolefins surfactants (PR demulsifiers).
View Article and Find Full Text PDFEvaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation.
Molecules
October 2023
UCL School of Pharmacy, University College London, 29/39 Bruunswick Square, London WC1N 1AX, UK.
Polymers, including non-linear copolymers, have great potential in the development of drug delivery systems with many advantages, but the design requires optimizing polymer-drug interactions. Molecular dynamics (MD) simulations can provide insights into polymer-drug interactions for designing delivery systems, but mimicking formulation processes such as drying is often not included in in silico studies. This study demonstrates an MD approach to model drying of systems comprising either hydrophilic tinidazole or hydrophobic clotrimazole drugs with amphiphilic hyperbranched copolyethers.
View Article and Find Full Text PDFPolyether-based waterborne synergists: effect of polymer topologies on pigment dispersion.
RSC Adv
October 2023
Center for Advanced Specialty Chemicals, Korea Research Institute of Chemical Technology Ulsan 44412 Republic of Korea
Control of polymer topologies is essential to determine their unique physical properties and potential applications. The polymer topologies can have a critical effect on pigment dispersion owing to their unique architectures; however, studies using polymer topologies on pigment dispersion in aqueous systems are scarce. Thus, this study proposes various topologies of polyether-based waterborne synergists, such as linear, hyperbranched, and branched cyclic structures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!