A significant reduction in morbidity and mortality can be achieved by using intensive insulin therapy to achieve normoglycemia in the critically ill patient. Nurses hourly titrate insulin infusion rates using protocols, most often in chart form, to guide practice. Despite the reported development of several intensive insulin protocols, information about the accuracy, practicality, ease of calculation, and preferences of critical care nurses have not been studied. The purpose of this study was to test a newly developed nomogram to determine if it was clinically practical, easily understood, and more quickly and accurately used than existing protocols in chart form. Three cohorts of nurses (N = 153), with an average of 9 years experience in critical care, performed calculations of insulin doses on the basis of hypothetical patient data, using chart and nomogram protocols. Time, accuracy, preference, and feedback were examined over all 3 phases. No statistical significance was found between the chart and nomogram methods regarding time to complete the calculations nor was there any significant effect of experience on the time it took to complete the calculations or the accuracy of the resultant answers. Overall, the accuracy of the calculations improved with each revision of the nomogram. The nurses did not have a preference of one tool over another but gave extensive feedback that helped refine the nomogram. The resultant nomogram was shown to be easy to use, helpful in improving the accuracy of insulin dosage calculation, and judged to be practical by the nurses who would use the tool at the bedside.
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http://dx.doi.org/10.1097/00002727-200601000-00011 | DOI Listing |
JCEM Case Rep
February 2025
Department of Medical Oncology, Kameda General Hospital, Chiba 296-0041, Japan.
Predicting the onset of type 1 diabetes mellitus (T1D) in patients treated with immune checkpoint inhibitors (ICI) remains challenging. ICI-induced T1D (ICI-T1D) is a rare but serious complication that leads to complete insulin depletion. While diabetes-associated autoantibodies, such as glutamic acid decarboxylase antibodies (GADA), are typically absent in non-ICI-related fulminant T1D, they are relatively common in ICI-T1D.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China.
Metabolic syndrome (Mets) in adolescents is a growing public health issue linked to obesity, hypertension, and insulin resistance, increasing risks of cardiovascular disease and mental health problems. Early detection and intervention are crucial but often hindered by complex diagnostic requirements. This study aims to develop a predictive model using NHANES data, excluding biochemical indicators, to provide a simple, cost-effective tool for large-scale, non-medical screening and early prevention of adolescent MetS.
View Article and Find Full Text PDFEur J Hosp Pharm
January 2025
Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, Utrecht, The Netherlands.
Objectives: Critically ill newborn infants often require simultaneous administration of multiple intravenous (IV) solutions through the same catheter lumen, making compatibility of these solutions crucial in neonatal intensive care units (NICUs). This study aimed to investigate the physical compatibility of insulin aspart, lidocaine, alprostadil and vancomycin with individualised two-in-one parenteral nutrition (PN).
Methods: The study was conducted at the hospital pharmacy's drug compounding facility of the University Medical Centre Utrecht.
Nutrients
January 2025
Diabetes and Endocrine Service, Liverpool Hospital, Sydney, NSW 2170, Australia.
Background: The optimal application of medical nutrition therapy (MNT) in treating gestational diabetes remains uncertain. MNT involves individualised nutrition assessment and counselling, which is labour-intensive and is not the sole type of intervention offered by clinical dietitians.
Objective: To determine whether pregnancy outcomes differed for individuals with gestational diabetes who were offered MNT on a risk-prioritised (RP) versus universal basis.
Pathogens
December 2024
Intensive Care Unit, Department of Anesthesiology and Critical Care, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Ventriculo-meningitis or nosocomial meningitis/ventriculitis is a severe nosocomial infection that is associated with devastating neurological sequelae. The cerebrospinal fluid isolates associated with the infection can be Gram-positive or -negative, while the spp. is rarely identified.
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