Motifs are small connected subnetworks that a network displays in significantly higher frequencies than would be expected for a random network. They have recently gathered much attention as a concept to uncover structural design principles of complex biological networks. FANMOD is a tool for fast network motif detection; it relies on recently developed algorithms to improve the efficiency of network motif detection by some orders of magnitude over existing tools. This facilitates the detection of larger motifs in bigger networks than previously possible. Additional benefits of FANMOD are the ability to analyze colored networks, a graphical user interface and the ability to export results to a variety of machine- and human-readable file formats including comma-separated values and HTML.
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http://dx.doi.org/10.1093/bioinformatics/btl038 | DOI Listing |
J Mater Chem B
January 2025
School of Materials Science and Engineering, University of New South Wales (UNSW Sydney), Sydney, NSW 2052, Australia.
Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and supramolecular interactions. In this communication, we expand the capabilities of covalent poly(ethylene glycol) (PEG) networks through co-assembly of supramolecular peptide nanofibers.
View Article and Find Full Text PDFMol Plant
January 2025
Leibniz Institut für Gemüse und Zierpflanzenbau (IGZ) e.V., Großbeeren, Germany; Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany. Electronic address:
Plants are able to sense and remember heat stress. An initial priming heat stress enables plants to acclimate so that they are able to survive a subsequent higher temperature. The heatshock transcription factors (HSFs) play a crucial role in this process, but the mechanisms by which plants sense heat stress are not well understood.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Background: Early-onset Alzheimer's disease (EOAD) is a complex disease that occurs at an early age at onset (AAO) before 65 years, constituting 5-6% of all AD cases and remains poorly understood. Patient-derived induced pluripotent stem cells (iPSCs) have been used to model different forms of EOAD that display heterogeneous disease mechanisms.
Method: We examined iPSC-derived neurons from both familial EOAD harboring mutations in PSEN1 , PSEN2, and APP and non-familial EOAD patients at an early AAO.
Mol Biotechnol
January 2025
Amity Institute of Biotechnology, Amity University, Kolkata, India.
Nine homologous Cold Shock Proteins (Csps) have been recognized in the E.coli Cold Shock Domain gene family. These Csps function as RNA chaperones.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Cu-based catalysts for the electrochemical reduction of CO and CO exhibit a perplexingly unique reactivity toward multicarbon based products compared to other studied electrocatalysts. Here we use insights gained from a recent phenomenological 3-site microkinetic model and grand-canonical density functional theory calculations to clarify the importance of an underemphasized aspect critical to Cu's unique reactivity: a population of so-called "reservoir" sites. Using model Cu surface motifs, we discuss how these types can be represented by undercoordinated structural defects like step edges and grain boundaries which form a network of highly anisotropic migration channels.
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