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Prenylated Chalcones From Roots of Kidney Vetch (Anthyllis vulneraria L.) With Antiproliferative Activity.
Chem Biodivers
February 2025
Department of Pharmaceutical Biology and Clinical Pharmacy, Institute of Pharmacy, Paracelsus Medical University, Salzburg, Austria.
Kidney vetch (Anthyllis vulneraria L.) is an old medicinal plant mostly known for ethnomedicine. Nowadays, its herbal parts are only scarcely used in phytotherapy, whereas medicinal applications of roots have not been reported so far.
View Article and Find Full Text PDFUrticalean Rosids Clade (Rosales): Deciphering the Riddle From a Chemical Point of View.
Chem Biodivers
February 2025
Laboratório de Ciências Químicas, Centro de Ciência e Tecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.
Cannabaceae, Moraceae, Ulmaceae and Urticaceae are members of the Urticalean rosids clade (Rosales). Their infrafamilial and infrageneric relationships remain poorly understood. The aim of this study was to assess chemical similarities and differences between families of the Urticalean rosids clade based on aromatic phenolic compounds.
View Article and Find Full Text PDF[Chemical constituents from stems and leaves of Artocarpus tonkinensis and their inhibitory effects on proliferation of synovioblasts in vitro].
Zhongguo Zhong Yao Za Zhi
July 2024
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University Haikou 571158, China Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University Haikou 571158, China Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University Haikou 571158, China Key Laboratory of Research and Development of Tropical Fruit and Vegetable of Haikou City, Hainan Normal University Haikou 571158, China.
The chemical constituents from the stems and leaves of Artocarpus tonkinensis in Artocarpus of Moraceae were systematically studied by means of silica gel, octadecylsilyl(ODS), and Sephadex LH-20 gel column chromatographies, as well as preparative high-performance liquid chromatography(Pre-HPLC) and a variety of chromatographic separation techniques. The spectral data and physicochemical properties of the compounds were obtained from separation and compared with those of the compounds reported in the literature. As a result, 11 compounds isolated from the 90% ethanol extract of the stems and leaves of A.
View Article and Find Full Text PDFAntimicrobial isoflavans and other metabolites of Dalea nana.
Phytochemistry
October 2024
Department of Chemistry, Western Washington University, Bellingham, WA, 98225, United States.
The phytochemical investigation of extracts from Dalea nana roots and aerial parts led to the isolation of thirteen phenolic compounds. Three previously undescribed isoflavans, named verdeans A-C (1, 3, and 7), were characterized. Two additional isoflavans (2 and 5) were previously undescribed enantiomers of known compounds.
View Article and Find Full Text PDFIntegration of Wnt-inhibitory activity and structural novelty scoring results to uncover novel bioactive natural products: new Bicyclo[3.3.1]non-3-ene-2,9-diones from the leaves of .
Front Chem
April 2024
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Centre Médical Universitaire, Geneva, Switzerland.
In natural products (NPs) research, methods for the efficient prioritization of natural extracts (NEs) are key for discovering novel bioactive NPs. In this study a biodiverse collection of 1,600 NEs, previously analyzed by UHPLC-HRMS metabolite profiling was screened for Wnt pathway regulation. The results of the biological screening drove the selection of a subset of 30 non-toxic NEs with an inhibitory IC ≤ 5 g/mL.
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