AI Article Synopsis
- Chloroma, also known as Granulocytic Sarcoma, is a rare type of cancer that originates from myeloid precursor cells and can occur outside the bone marrow, often linked to myelo-proliferative disorders or can appear before leukemia develops.
- It can manifest in various locations in the body, although appearance in the head and neck is uncommon, making diagnosis challenging as it can resemble other conditions like acute lymphoblastic leukemia or Ewing's sarcoma.
- The text discusses a specific case of chloroma located in the maxillo-ethmoidal area of a patient with poor prognosis acute myeloid leukemia, highlighting the clinical features and challenges in accurate diagnosis.
Article Abstract
Chloroma, also called Granulocytic Sarcoma or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myelo-proliferative disorders but its appearance may precede the onset of leukaemia. Chloroma may be found in several extracranial sites. Involvement of the head and neck region is uncommon. Differential diagnosis is often difficult and includes acute lymphoblastic leukaemia, large cell NHL, lymphoblastic lymphoma and Ewing's sarcoma. The case is presented of a maxillo-ethmoidal chloroma occurring in a case of poor prognosis acute myeloid leukaemia, emphasizing the clinical and cyto-histological features and problems concerning differential diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639872 | PMC |
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