AI Article Synopsis
- Surgical resection is the primary treatment for early-stage non-small-cell lung cancer, providing the best chance for a cure, but has high recurrence rates when used alone.
- Recent studies, including a meta-analysis and four randomized trials, support the use of adjuvant platinum-based chemotherapy to reduce these recurrence rates.
- Adjuvant chemotherapy can improve 5-year survival rates by about 5%-15%, making it the recommended treatment following surgical resection for patients with completely removed tumors in stages I, II, and IIIA.
Article Abstract
Background: Surgical resection remains the cornerstone of therapy for early-stage disease and offers the best chance for cure. Local and distant failure rates, however, remain unacceptably high with surgery alone. Radiation and systemic chemotherapy have been used to reduce recurrences in early-stage disease. Neoadjuvant and adjuvant strategies both offer sound theoretical benefit, but evidence supporting this has been lacking. The publication of a meta-analysis in 1995 triggered a reevaluation of adjuvant chemotherapy. Four randomized trials reported in the last 2 years support the use of adjuvant platinum-based chemotherapy.
Methods: This article reviews the history of clinical trials evaluating neoadjuvant and adjuvant therapy in non-small-cell lung cancer.
Results: Adjuvant chemotherapy improves 5-year survival rates by approximately 5%-15% compared with surgery alone.
Conclusions: Surgical resection followed by adjuvant chemotherapy is the standard of care treatment for patients with completely resected stage I, II, and IIIA non-small-cell lung cancer.
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| http://dx.doi.org/10.1245/ASO.2006.01.015 | DOI Listing |
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