AI Article Synopsis
- Rectal adenocarcinoma with diffuse oncocytic features is extremely rare and has only been previously reported once; this case involves a 66-year-old man with a tumor associated with a villous adenoma.
- Histological analysis revealed that the adenocarcinoma had neoplastic glands with a distinctive eosinophilic, granular epithelium, infiltrating deeply into the rectal wall, and contained basophilic calcifications in the gland lumina.
- Immunohistochemical profiling showed strong reactions to specific markers, and the text briefly discusses molecular changes related to oncocytic features and their potential role in the development of cancer.
Article Abstract
Rectal adenocarcinoma with diffuse oncocytic features is a very rare lesion, having been reported only once in the English literature. We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man. On histological examination, the adenocarcinoma was composed of neoplastic glands lined by a strongly eosinophilic, granular epithelium that deeply infiltrated the rectal wall. Some basophilic calcifications were present in the gland lumina. Superficially, a villous adenoma with high-grade dysplasia was evident; adenomatous cells showed focal eosinophilic changes, consisting of a large granular cytoplasm, an oval atypical nucleus, and a prominent nucleolus. Immunohistochemically, neoplastic glands reacted strongly with antimitochondria antibody, carcinoembryonic antigen, cytokeratin 20, p53, and CDX2. Molecular alterations observed in oncocytic changes and their significance with regards to neoplastic transformation are briefly discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00428-005-0148-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!