AI Article Synopsis
- The study aimed to compare two plasma cuproenzymes, PAM and ceruloplasmin, as markers of copper status in neonatal mammals.
- During dietary copper deficiency, ceruloplasmin activity increased in lactating dams while PAM activity decreased, with a more significant reduction in ceruloplasmin for both offspring and mothers.
- The differences in cuproenzyme activity highlight their potential as indicators of copper status, especially when dietary copper is limited during early development.
Article Abstract
In an attempt to identify a sensitive and improved marker of mammalian copper status during neonatal development experiments compared two plasma cuproenzymes, peptidylglycine alpha-amidating monooxygenase (PAM ), an enzyme involved in peptide posttranslational activation, to ceruloplasmin (Cp), a ferroxidase involved in iron mobilization. Dietary Cu deficiency (Cu-) was studied in dams and offspring at postnatal age 3 (P3), P12, and P28. Rodent Cp activity rose during lactation whereas PAM activity fell. Reduction in Cp activity was more severe than reduction in PAM activity in Cu- offspring and dams. Cp activity was greater in rats than mice whereas PAM activity was similar in adults but greater in mouse than rat pups. Both cuproenzymes changed during neonatal development and when dietary copper was limiting. With proper controls, each enzyme can be used to assess copper status.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716669 | PMC |
| http://dx.doi.org/10.1016/j.cbpb.2005.12.010 | DOI Listing |
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