Summarized are the results of comparative analysis of morphological changes in rat's skeletal muscles after microgravity and its simulation. On completion of space flight, hindlimb muscles of rats exhibited atrophy developed in space microgravity in consequence of the lack of weight-bearing loads and changes solely in the slow anti-g muscles due to the hemodynamic disorders appearing after space flight. Immobilization combined with clinostatting cannot be a veridical laboratory model of microgravity, as horizontally positioned animals still possess weight and, besides, experience severe chronic stress of immobilization. Tail suspension with the head-end permanently down and the hind limbs out of use appeared the most demonstrative model of the space microgravity effects. With this model, the hindlimb muscles underwent changes identical to what had been observed in space flown animals. Data of the simulation studies suggest stabilization of muscle atrophy at a certain level and an earlier and stronger reaction to the hindlimb unloading in young rats as compared to old animals. Skeletal muscles in females and males responded to suspension similarly in spite of difference in the hormonal status.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
In situ spatial transcriptomic analysis of human skeletal muscle using the Xenium platform.
Cell Tissue Res
January 2025
Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Traditional transcriptomic studies often overlook the complex heterogeneity of skeletal muscle, as they typically isolate RNA from mixed muscle fibre and cell populations, resulting in an averaged transcriptomic profile that obscures fibre type-specific differences. This study assessed the potential of the recently developed Xenium platform for high-resolution spatial transcriptomic analysis of human skeletal muscle histological sections. Human vastus lateralis muscle samples from two individuals were analysed using the Xenium platform and Human Multi-Tissue and Cancer Panel targeting 377 genes complemented by staining of successive sections for Myosin Heavy Chain isoforms to differentiate between type 1 and type 2 muscle fibres.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Medical College, the Catholic University of Korea, Seoul, Korea, Republic of (South).
Background: Although previous studies have demonstrated cognitive impairment in elderly individuals with sarcopenia and its neuronal substrates, there is no comprehensive model integrating multiple brain pathologies to predict cognitive impairment associated with sarcopenia. The aim of this study was to explore a comprehensive prediction model for cognitive impairment in sarcopenia using multimodal neuroimaging methods in non-demented older adults.
Method: This cross-sectional study used data from the Catholic Aging Brain Imaging Database study, a population-based cohort study with magnetic resonance imaging (MRI) scans, positron emission tomography (PET) scans, and clinical data.
Biomarkers.
Alzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Background: Within the research field of neurodegenerative disorders, unbiased analysis of body fat composition, particularly muscle mass, is gaining attention as a potential biological marker for refining Alzheimer's disease risk. The objective of this study was to employ a deep learning model for fully automated and accurate segmentation of thigh tissues, potentially contributing to early Alzheimer's diagnostics.
Method: In an IRB-approved study, 49 participants underwent thigh Dixon MRI scans with a TR=9.
Biomarkers.
Alzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Background: Emerging research underscores the significance of midlife obesity, defined by a BMI of 30 kg/m or higher in persons age 40-60 years, as a risk factor for Alzheimer's disease (AD) in later life. Due to the various properties of each body component, it is important to characterize the neurodegenerative effects of fat within the muscle, known as a predictor of metabolic health and cognition. We investigated the relationships between thigh total fat-to-muscle ratio (FMR) and brain cortical thickness in cognitively normal midlife individuals.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
USC Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Background: Alzheimer's disease (AD) is associated with complex pathophysiology including synaptic dysregulation, compromised neurotrophic signaling, deficits in autophagic flux and neuroinflammation). Skeletal muscle regulates many brain functions relevant to aging, by activating the muscle-to-brain axis through the secretion of skeletal muscle originating factors (myokines) with cellular-modifying, neuro and geroprotective properties. Our group developed transgenic mice that overexpress the skeletal muscle human Transcription Factor EB (TFEB), a master regulator of lysosomal-to-nucleus signaling, resulting in enhanced proteostasis and neuroprotection in a Tau mouse model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!