Objective: To verify the hypothesis that selected nestin positive cells derived from human fetal pancreas (according as medical ethnics) have surface markers similar to bone marrow mesenchymal stem cells (MSCs), and that these cells have multilineage potential.
Method: The cell surface markers were determined by flow cytometry, and then the potential that these cells might be differentiated into adipocytes and osteoplasts were explored.
Result: These cells have similar surface markers as MSCs of bone marrow origin. These cells was induced to differentiate into adipocytes and osteoplasts.
Conclusion: Selected nestin positive cells derived from human fetal pancreas have certain characteristics of MSCs.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Experimental study of cBMMSC based on nanosilver hydrogel nerve conduit for repairing spinal cord injury.
J Cell Mol Med
November 2024
Center for Rehabilitation Medicine, Department of Neurosurgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Article Synopsis
- * The experimental group received cBMMSC-infused conduits, while the control group had conduits without these cells; both groups were evaluated for neuron-like cell differentiation, neuronal regeneration, and axon growth after four weeks.
- * Various methods, including immunostaining and Western blotting, were employed to assess neural recovery and functional outcomes, such as motor ability and nerve impulse transmission, in both groups.
Increasing adult-born neurons protects mice from epilepsy.
Elife
October 2024
Center for Dementia Research, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, United States.
Neurogenesis occurs in the adult brain in the hippocampal dentate gyrus, an area that contains neurons which are vulnerable to insults and injury, such as severe seizures. Previous studies showed that increasing adult neurogenesis reduced neuronal damage after these seizures. Because the damage typically is followed by chronic life-long seizures (epilepsy), we asked if increasing adult-born neurons would prevent epilepsy.
View Article and Find Full Text PDFSelective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury.
J Neuroinflammation
October 2024
Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1 (Bld. 505), 55131, Mainz, Germany.
Article Synopsis
- Progranulin (PGRN) is a neurotrophic and anti-inflammatory protein, and its loss due to human mutations is linked to frontotemporal dementia, with PGRN knockout (KO) mice used to model this condition.
- Restoration of PGRN in neurons (but not microglia) was achieved in a specific mouse model, allowing researchers to investigate if it could reduce brain damage after traumatic brain injury (TBI).
- Findings indicated that restoring PGRN in neurons was enough to mitigate excessive brain damage caused by TBI, suggesting that microglial PGRN was not necessary for neuroprotection and anti-inflammatory effects in this context.
GluN2B on Adult-Born Granule Cells Modulates (R,S)-Ketamine's Rapid-Acting Effects in Mice.
Int J Neuropsychopharmacol
October 2024
Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Background: Standard antidepressant treatments often take weeks to reach efficacy and are ineffective for many patients. (R,S)-ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be a rapid-acting antidepressant and to decrease depressive symptoms within hours of administration. While previous studies have shown the importance of the GluN2B subunit of the NMDA receptor on interneurons in the medial prefrontal cortex, no study to our knowledge has investigated the influence of GluN2B-expressing adult-born granule cells.
View Article and Find Full Text PDFIn vitro cytotoxicity assessment of ruxolitinib on oligodendrocyte precursor cell and neural stem/progenitor cell populations.
Neurotoxicology
December 2024
Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Department of Human Anatomy, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; Malaysian Research Institute on Ageing (MyAgeing™), Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia. Electronic address:
JAK-STAT signaling cascade has emerged as an ideal target for the treatment of myeloproliferative diseases, autoimmune diseases, and neurological disorders. Ruxolitinib (Rux), is an orally bioavailable, potent and selective Janus-associated kinase (JAK) inhibitor, proven to be effective to target activated JAK-STAT pathway in the diseases previously described. Unfortunately, limited studies have investigated the potential cytotoxic profile of Rux on other cell populations within the heterogenous CNS microenvironment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!