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Periorbital necrobiotic xanthogranuloma resolved with three years of systemic lenalidomide treatment.

Am J Ophthalmol Case Rep

March 2025

Ophthalmic Surgeons and Consultants of Ohio, Columbus, OH, USA.

Purpose: To describe a case report of the successful management of necrobiotic xanthogranuloma (NXG), a rare periorbital disease.

Observations: A 61-year-old patient presented with bilateral upper and lower lid lesions which were initially misdiagnosed as xanthelasmas and later confirmed to be NXG. Further investigation also uncovered a diagnosis of multiple myeloma.

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Objective: We sought to analyze the effectiveness, recurrence, safety, and patient satisfaction rates following xanthelasma palpebrarum (XP) treatment with trichloroacetic acid (TCA) 80%.

Methods: This was a retrospective review of patients treated with TCA 80% for XP between January 2012 and August 2022. A prospective telephone questionnaire was administered to the same patient population to evaluate recurrence, patient satisfaction, and side effects.

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Aim: The aim of this study was to examine the clinical, laboratory and demographic characteristics of patients diagnosed with cerebrotendinous xanthomatosis.

Materials And Methods: This study included 11 patients followed up in the Paediatric Metabolism Polyclinic for a diagnosis of CTX. The diagnosis of CTX was made from high blood cholestanol level and CYP27A1 gene analysis.

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Article Synopsis
  • Xanthomas are benign, yellow, soft skin lesions made up of fat-laden immune cells, often indicating underlying lipid issues in the body.
  • A 13-year-old girl had large, painless nodules on her elbows and knees for five years, and tests revealed a family history of similar lesions with abnormal lipid levels.
  • The case emphasizes the need for early diagnosis of xanthomas to prevent serious health problems like heart disease and strokes in young patients.
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Article Synopsis
  • * A 49-year-old woman in Oman experienced recurring facial masses and developed additional health issues, including infertility and diabetes insipidus, over a 10-year period.
  • * Biopsy results revealed distinct features of ECD, and this case is notable as it appears to be the first reported instance of ECD in Oman; the patient is currently stable and under observation.
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