Bves, a member of the Popeye domain-containing gene family.

Dev Dyn

Stahlman Cardiovascular Laboratories, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232-6300, USA.

Published: March 2006

Bves was discovered through subtractive screens designed to identify heart-enriched transcripts. Bves is a transmembrane protein that possesses a highly conserved structure among species of the animal kingdom. Various approaches have been used to elucidate the expression pattern of Bves mRNA and protein as well as its function in developing and mature organisms. Emerging evidence indicates that this protein is present in muscle and epithelia of developing embryos and the adult. In vitro functional studies predict a role in cell-cell interaction and/or adhesion. In vivo analysis of protein function is very limited at present, but recent work in Xenopus supports the importance of Bves in epithelial integrity. Presented in this review is a compilation of published findings concerning Bves gene and protein characteristics, expression patterns in embryos and cells, and functional significance as determined thus far. Presently, the literature supports a hypothesis that Bves is essential to the junctional architecture of muscle and epithelial cell types. Although there remain aspects of Bves structure, expression, and function that are not completely resolved, now is an appropriate time to summarize current knowledge about this protein, the remaining questions, and what its potential role in development might be. This review will serve as a departure point for others who become interested in the study of this highly conserved protein.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849751PMC
http://dx.doi.org/10.1002/dvdy.20688DOI Listing

Publication Analysis

Top Keywords

bves
8
highly conserved
8
protein
7
bves member
4
member popeye
4
popeye domain-containing
4
domain-containing gene
4
gene family
4
family bves
4
bves discovered
4

Similar Publications

Magnetic Resonance Imaging-Based Radiogenomic Analysis Reveals Genomic Determinants for Nanoparticle Delivery into Tumors.

ACS Nano

December 2024

State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University, Nanjing 211102, P. R. China.

Article Synopsis
  • The EPR effect helps nanodrugs target solid tumors, but variability in this effect has hindered clinical success, making its mechanisms important to study.
  • This study aimed to develop a method that combines radiogenomics and MRI to better understand how nanoparticles (NPs) penetrate tumors using a contrast agent made from PLGA-coated FeO NPs.
  • Through gene enrichment analyses, key genes influencing vascular permeability were identified, which can enhance the understanding of how NPs behave in tumor environments, ultimately supporting personalized treatment strategies.
View Article and Find Full Text PDF
Article Synopsis
  • * ELISA has been suggested as an easier alternative but struggles with antigen availability, particularly RABV glycoprotein, which requires high biosafety levels for use.
  • * The research tested insect cell extracts producing RABV glycoprotein and found it effectively detected rabies antibodies in vaccinated dogs, with a 90.48% sensitivity and 80.00% specificity, making it suitable for quick screening and monitoring vaccination efforts.
View Article and Find Full Text PDF

Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release.

Ultrason Sonochem

January 2025

Division of Advanced Mechanical Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei-shi, Tokyo 184-8588, Japan. Electronic address:

Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies.

View Article and Find Full Text PDF

Objective: This study aims to investigate the expression profile of miRNAs significantly dysregulated after acute myocardial infarction (AMI) and their potential targets.

Methods: After the establishment of a mouse model of AMI, RNA was extracted from mouse infarcted myocardium. Paired-end sequencing was then performed using the Illumina NovaSeq 6000 system to explore the expression profile of miRNAs.

View Article and Find Full Text PDF

Development of a Ferritin-Based Nanoparticle Vaccine against Classical Swine Fever.

Vaccines (Basel)

August 2024

College of Veterinary Medicine, South China Agricultural University, No. 483 Wushan Road, Tianhe District, Guangzhou 510642, China.

The occurrence of classical swine fever (CSF) poses a significant threat to the global swine industry. Developing an effective and safe vaccine is crucial for preventing and controlling CSF. Here, we constructed self-assembled ferritin nanoparticles fused with the classical swine fever virus (CSFV) E2 protein and a derived B cell epitope (Fe-E2B) using a baculovirus expression system (BVES), demonstrating enhanced immunogenicity.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!