Calcium-activated potassium channels and the regulation of vascular tone.

Physiology (Bethesda)

Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA.

Published: February 2006

AI Article Synopsis

  • Different calcium signals in endothelial cells and smooth muscle cells influence distinct Ca2+-sensitive K+ channels.
  • These channels play a key role in regulating vascular functions.
  • Understanding these variations opens up new possibilities for preventing or treating vascular dysfunctions.

Article Abstract

Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.

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Source
http://dx.doi.org/10.1152/physiol.00040.2005DOI Listing

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