AI Article Synopsis
- Intestinal non-Hodgkin's lymphoma (NHL), particularly the T-cell type, is linked to celiac disease (CD), which is more common in certain genetic backgrounds and is marked by GI symptoms and specific antibodies.
- In Asian populations, including Japan, CD and its relationship with NHL are considered rare, with limited research available.
- A case study of a Japanese man with diffuse large B-cell lymphoma associated with CD showed improvement after chemotherapy and following a gluten-free diet, highlighting the need to consider this association in similar populations.
Article Abstract
Intestinal non-Hodgkin's lymphoma (NHL), especially the T-cell type, is well known to be associated with celiac disease (CD), an enteropathic disorder with a propensity for certain racial and genetic backgrounds. CD is typically characterized by gastrointestinal (GI) symptoms, anti-transglutaminase antibodies in the sera, and microscopical findings of the intestinal mucosa, which resolve with a gluten-free diet (GFD). In Asian populations, including the Japanese, CD and the associated NHL have been supposed to be quite rare, and studies concerning the frequency of CD or its relationship with NHL are scarce. We describe a Japanese middle-aged man with intestinal diffuse large B-cell lymphoma associated with CD. Following multi-combined chemotherapy, the patient's lymphoma has been in a state of complete response, and his GI symptoms have improved with a GFD. This case suggests that the possibility of CD and its association with intestinal NHL should be kept in mind, even in Asian populations.
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| http://dx.doi.org/10.1532/IJH97.05131 | DOI Listing |
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